Blueprint Medicines Announces Enrollment of First Patient in Phase 1 Clinical Trial for BLU-667
"By rapidly initiating a clinical trial for our potent and selective RET inhibitor BLU-667, we have successfully achieved a key 2017 milestone," said
"RET fusions and mutations are recognized as important drivers in multiple cancers, but existing multi-kinase inhibitors with RET activity do not provide sufficient, durable benefit for patients with RET alterations," said
BLU-667 is an orally available, potent and selective inhibitor designed to target RET mutations, fusions and predicted resistance mutants. RET activating fusions and mutations are a key disease driver in multiple cancers, including NSCLC and MTC, with RET fusions implicated in approximately 1-2% of patients with NSCLC, and RET mutations implicated in approximately 60% of patients with MTC. In addition, genomic analyses published by scientists at
About the Phase 1 Clinical Trial for BLU-667 in RET
About
Blueprint Medicines is developing a new generation of targeted and potent kinase medicines to improve the lives of patients with genomically defined diseases. Its approach is rooted in a deep understanding of the genetic blueprint of cancer and other diseases driven by the abnormal activation of kinases. Blueprint Medicines is advancing four programs in clinical development for subsets of patients with gastrointestinal stromal tumors, hepatocellular carcinoma, systemic mastocytosis, non-small cell lung cancer, medullary thyroid cancer and other advanced solid tumors, as well as multiple programs in research and preclinical development.
Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, statements regarding plans and timelines for the clinical development of BLU-667;
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/blueprint-medicines-announces-enrollment-of-first-patient-in-phase-1-clinical-trial-for-blu-667-300426336.html
SOURCE
Investor Relations: Kristin Williams, Blueprint Medicines Corporation, 617-714-6674, kwilliams@blueprintmedicines.com; Media Relations: Rachel Hutman, W20 Group, 301-801-5540, rhutman@wcgworld.com