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Cover
Document and Entity Information
Financial Statements
Consolidated Balance Sheets
Consolidated Balance Sheets (Parenthetical)
Consolidated Statements of Operations and Comprehensive Loss
Consolidated Statements of Stockholders' Equity
Consolidated Statements of Cash Flows
Consolidated Statements of Cash Flows (Parenthetical)
Notes to Financial Statements
Nature of Business
Summary of Significant Accounting Policies and Recent Accounting Pronouncements
Financing Arrangements
Marketable Securities
Fair Value of Financial Instruments
Product Revenue and Related Reserves
Inventory
Restricted Cash
Property and Equipment, Net
Accrued Expenses
Collaboration and License Agreements
Acquisition
Stock-based Compensation
Net Loss per Share
Income Taxes
Leases
Employee Benefit Plans
Commitments and Contingencies
Accounting Policies
Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Policies)
Notes Tables
Financing Arrangements (Tables)
Marketable Securities (Tables)
Fair Value of Financial Instruments (Tables)
Product Revenue and Related Reserves (Tables)
Inventory (Tables)
Property and Equipment, Net (Tables)
Accrued Expenses (Tables)
Collaboration and License Agreements (Tables)
Acquisition (Tables)
Stock-based Compensation (Tables)
Net Loss per Share (Tables)
Income Taxes (Tables)
Leases (Tables)
Employee Benefit Plans (Tables)
Notes Details
Nature of Business (Details)
Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Accounts Receivable, Net (Details)
Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Selling, General and Administrative Expenses (Details)
Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Impairment of Long-Lived Assets (Details)
Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Stock-Based Compensation Expense (Details)
Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Segment and Geographic Information (Details)
Financing Arrangements - General Information (Details)
Financing Arrangements - Royalty and Sales Information (Details)
Financing Arrangements - Long-term Debt (Details)
Financing Arrangements - Roll Forward (Details)
Financing Arrangements - Estimated Total Gross Payments (Details)
Financing Arrangements - Additional Information (Details)
Marketable Securities - Tabular Disclosure (Details)
Marketable Securities - Maturities (Details)
Marketable Securities - Unrealized Loss Positions (Details)
Marketable Securities - Impairment (Details)
Marketable Securities - Proceeds from Maturities (Details)
Marketable Securities - Realized Gains (Losses) (Details)
Fair Value of Financial Instruments (Details)
Product Revenue and Related Reserves - Product Revenue (Details)
Product Revenue and Related Reserves - Concentration Risk (Details)
Product Revenue and Related Reserves - Product Revenue Allowance and Reserve (Details)
Product Revenue and Related Reserves - Revenue-related Reserves (Details)
Inventory - Capitalized (Details)
Inventory - Balance Sheet Classification (Details)
Inventory - Write-down (Details)
Restricted Cash (Details)
Property and Equipment, Net - Estimated Useful Lives (Details)
Property and Equipment, Net - Property and Equipment and Related Accumulated Depreciation (Details)
Property and Equipment, Net - Depreciation Expense (Details)
Accrued Expenses (Details)
Collaboration and License Agreements - General Information (Details)
Collaboration and License Agreements - Transaction Price (Details)
Collaboration and License Agreements - Equity Investment (Details)
Collaboration and License Agreements - Sale of Stock (Details)
Collaboration and License Agreements - Revenue Recognized (Details)
Collaboration and License Agreements - Collaboration Loss Sharing (Details)
Collaboration and License Agreements - Reduction in Expenses (Details)
Collaboration and License Agreements - Change in Contract with Customer, Liability (Details)
Collaboration and License Agreements - Contract Assets and Liabilities (Details)
Collaboration and License Agreements - Performance Obligations (Details)
Acquisition - Consideration Transferred (Details)
Acquisition - Acquired Intellectual Property (Details)
Acquisition - Purchase Price (Details)
Acquisition - Identifiable Net Assets Acquired (Details)
Stock-based Compensation - 2015 Stock Option and Incentive Plan (Details)
Stock-based Compensation - 2020 Inducement Plan (Details)
Stock-based Compensation - Stock-based Compensation Expense - General Information (Details)
Stock-based Compensation - Stock-based Compensation Expense - By Type (Details)
Stock-based Compensation - Stock-based Compensation Expense - By Classification (Details)
Stock-based Compensation - Unrecognized Compensation Costs (Details)
Stock-based Compensation - Awards - General Information (Details)
Stock-based Compensation - Stock Options - Weighted Average Assumptions (Details)
Stock-based Compensation - Stock Options - Activity (Details)
Stock-based Compensation - Stock Options - Additional Information (Details)
Stock-based Compensation - Unvested Awards - Activity (Details)
Stock-based Compensation - Restricted Stock Units - Additional Information (Details)
Stock-based Compensation - Performance-based Restricted Stock Units (Details)
Stock-based Compensation - Employee Stock Purchase Plan (Details)
Net Loss per Share (Details)
Income Taxes - Reconciliation (Details)
Income Taxes - Deferred Tax Assets and Liabilities (Details)
Income Taxes - Valuation Allowance (Details)
Income Taxes - Net Operating Loss Carryforwards (Details)
Income Taxes - Tax Credit Carryforwards (Details)
Income Taxes - Financing Arrangements (Details)
Income Taxes - Equity Investment (Details)
Income Taxes - Expense (Benefit) (Details)
Income Taxes - Unrecognized Tax Benefits - General Information (Details)
Income Taxes - Unrecognized Tax Benefits - Roll Forward (Details)
Leases - General Information (Details)
Leases - Components of Lease Expense (Details)
Leases - Cash Flow Information (Details)
Leases - Weighted Average Remaining Lease-term and Weighted Average Discount Rate (Details)
Leases - Future Minimum Lease Payments (Details)
Leases - Total Lease Liability (Details)
Employee Benefit Plans - 401(k) Savings Plan (Details)
Employee Benefit Plans - Switzerland Defined Benefit Plan - General Information (Details)
Employee Benefit Plans - Switzerland Defined Benefit Plan - Tabular Disclosure (Details)
Employee Benefit Plans - Switzerland Defined Benefit Plan - Net Periodic Benefit Cost (Details)
Employee Benefit Plans - Switzerland Defined Benefit Plan - Contributions (Details)
Employee Benefit Plans - Switzerland Defined Benefit Plan - Expected Benefit Payments (Details)
Commitments and Contingencies - Purchase Commitments (Details)
Commitments and Contingencies - Indemnification Agreements (Details)
Notes to Financial Statements
Pay vs Performance Disclosure
Insider Trading Arrangements
All Reports