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  <element id="bpmc_CollaborativeArrangementMilestonesDevelopmentAndRegulatoryMilestonesContingentPaymentsEligibleToReceive" name="CollaborativeArrangementMilestonesDevelopmentAndRegulatoryMilestonesContingentPaymentsEligibleToReceive" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMilestonesSalesBasedMilestonesContingentPaymentsEligibleToReceive" name="CollaborativeArrangementMilestonesSalesBasedMilestonesContingentPaymentsEligibleToReceive" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMaterialComponentsNumber" name="CollaborativeArrangementMaterialComponentsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementLicensedProductTermFromFirstCommercialSale" name="CollaborativeArrangementLicensedProductTermFromFirstCommercialSale" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementLicenseOptionRightsNumber" name="CollaborativeArrangementLicenseOptionRightsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsWithExclusiveCommercializationRightsNumber" name="CollaborativeArrangementCollaborationProgramsWithExclusiveCommercializationRightsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsNumber" name="CollaborativeArrangementCollaborationProgramsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsLicensedProductsCommercializationRightsCounterpartyExercisesOptionCounterpartyReceivesWorldwideExclusivityNumber" name="CollaborativeArrangementCollaborationProgramsLicensedProductsCommercializationRightsCounterpartyExercisesOptionCounterpartyReceivesWorldwideExclusivityNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsLicensedProductsCommercializationRightsCounterpartyExercisesOptionEntityRetainsDomesticAndCounterpartyReceivesInternationalNumber" name="CollaborativeArrangementCollaborationProgramsLicensedProductsCommercializationRightsCounterpartyExercisesOptionEntityRetainsDomesticAndCounterpartyReceivesInternationalNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementOptionFeesAndMilestonesPreClinicalAndClinicalDevelopmentEventsPriorToLicensingContingentPaymentsEligibleToReceive" name="CollaborativeArrangementOptionFeesAndMilestonesPreClinicalAndClinicalDevelopmentEventsPriorToLicensingContingentPaymentsEligibleToReceive" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriod" name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveNotBeenCommerciallySold" name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveNotBeenCommerciallySold" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveBeenCommerciallySold" name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveBeenCommerciallySold" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMilestonesResearchMilestonesAchieved" name="CollaborativeArrangementMilestonesResearchMilestonesAchieved" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementManufacturingAndResearchAndDevelopmentServicesRelatedToGlobalDevelopmentActivitiesNetOfCostSharingPayments" name="CollaborativeArrangementManufacturingAndResearchAndDevelopmentServicesRelatedToGlobalDevelopmentActivitiesNetOfCostSharingPayments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InventoryCurrentAndNoncurrentNet" name="InventoryCurrentAndNoncurrentNet" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InventoryCurrentAndNoncurrentWorkInProcessNetOfReserves" name="InventoryCurrentAndNoncurrentWorkInProcessNetOfReserves" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InventoryCurrentAndNoncurrentFinishedGoodsNetOfReserves" name="InventoryCurrentAndNoncurrentFinishedGoodsNetOfReserves" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ScheduleOfInventoryCurrentAndNoncurrentTableTextBlock" name="ScheduleOfInventoryCurrentAndNoncurrentTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_AtMarketOfferingMember" name="AtMarketOfferingMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_FollowOnPublicOfferingAndAtMarketOfferingMember" name="FollowOnPublicOfferingAndAtMarketOfferingMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OperatingLossCarryforwardsUnlimitedCarryforward" name="OperatingLossCarryforwardsUnlimitedCarryforward" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OperatingLossCarryforwardsLimitationsOnUseAvailableForUtilization" name="OperatingLossCarryforwardsLimitationsOnUseAvailableForUtilization" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTransactionPriceCashConsiderationReceived" name="CollaborativeArrangementTransactionPriceCashConsiderationReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMaterialPromisesManufacturingActivitiesTerm" name="CollaborativeArrangementMaterialPromisesManufacturingActivitiesTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_AtMarketOfferingAmountAuthorizedAggregateOfferingPrice" name="AtMarketOfferingAmountAuthorizedAggregateOfferingPrice" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTransactionPriceMilestonePaymentsReceivedAndReceivable" name="CollaborativeArrangementTransactionPriceMilestonePaymentsReceivedAndReceivable" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <xsd:element name="InventoryCurrentAndNoncurrentRawMaterialsNetOfReserves" id="bpmc_InventoryCurrentAndNoncurrentRawMaterialsNetOfReserves" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ScheduleOfCollaborationLossSharingTableTextBlock" id="bpmc_ScheduleOfCollaborationLossSharingTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="GavretoMember" id="bpmc_GavretoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AyvakitAndAyvakytMember" id="bpmc_AyvakitAndAyvakytMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementCommercializationReductionInSellingGeneralAndAdministrativeExpenses" id="bpmc_CollaborativeArrangementCommercializationReductionInSellingGeneralAndAdministrativeExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementGlobalDevelopmentActivitiesReductionInResearchAndDevelopmentExpenses" id="bpmc_CollaborativeArrangementGlobalDevelopmentActivitiesReductionInResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ScheduleOfAmountsRecognizedAsReductionsToExpensesCollaborativeArrangementTableTextBlock" id="bpmc_ScheduleOfAmountsRecognizedAsReductionsToExpensesCollaborativeArrangementTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LengoTherapeuticsIncMember" id="bpmc_LengoTherapeuticsIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AcquiredProductiveAssetsInProcessResearchAndDevelopmentExpensed" id="bpmc_AcquiredProductiveAssetsInProcessResearchAndDevelopmentExpensed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AccountingStandardsUpdate202110Member" id="bpmc_AccountingStandardsUpdate202110Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DefinedContributionPlanAbstract" id="bpmc_DefinedContributionPlanAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AssetAcquisitionConsiderationTransferredUpfrontPayment" id="bpmc_AssetAcquisitionConsiderationTransferredUpfrontPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssetAcquisitionConsiderationTransferredFutureContingentCashMilestonePayments" id="bpmc_AssetAcquisitionConsiderationTransferredFutureContingentCashMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssetAcquisitionConsiderationTransferredAdjustmentsNetIndebtednessTransactionExpensesAndOtherAdjustments" id="bpmc_AssetAcquisitionConsiderationTransferredAdjustmentsNetIndebtednessTransactionExpensesAndOtherAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesNet" id="bpmc_AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ZaiLabShanghaiCoLtdMember" id="bpmc_ZaiLabShanghaiCoLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementMaterialPromisesCombinedIntoDistinctPerformanceObligationNumber" id="bpmc_CollaborativeArrangementMaterialPromisesCombinedIntoDistinctPerformanceObligationNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDate" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDate" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenAfterFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenAfterFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenPriorToFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenPriorToFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="TerritorySpecificActivitiesManufacturingServicesAndRoyaltyMember" id="bpmc_TerritorySpecificActivitiesManufacturingServicesAndRoyaltyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementMilestonesDevelopmentMilestonesAchieved" id="bpmc_CollaborativeArrangementMilestonesDevelopmentMilestonesAchieved" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LesseeOperatingSubleaseReceivablesNetDue" id="bpmc_LesseeOperatingSubleaseReceivablesNetDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
</xsd:schema>
