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  <element id="bpmc_NetProceedsFromStockOptionExercisesAndEmployeeStockPurchasePlan" name="NetProceedsFromStockOptionExercisesAndEmployeeStockPurchasePlan" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ClementiaMember" name="ClementiaMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_LeaseRightOfUseAssetAmortization" name="LeaseRightOfUseAssetAmortization" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborationMember" name="CollaborationMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InducementPlan2020Member" name="InducementPlan2020Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_AccruedContractWithCustomerAssetAccumulatedAllowanceForCreditLoss" name="AccruedContractWithCustomerAssetAccumulatedAllowanceForCreditLoss" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ExternalResearchDevelopmentAndCommercialContractCostsCurrent" name="ExternalResearchDevelopmentAndCommercialContractCostsCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborationProfitLossSharing" name="CollaborationProfitLossSharing" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_StockIssuedDuringPeriodValueNewIssuesPremium" name="StockIssuedDuringPeriodValueNewIssuesPremium" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_StockIssuedDuringPeriodValueNewIssuesPurchaseConsideration" name="StockIssuedDuringPeriodValueNewIssuesPurchaseConsideration" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_RocheCollaborationAndLicenseImmunotherapyAgreementMember" name="RocheCollaborationAndLicenseImmunotherapyAgreementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_RocheCollaborationPralsetnibAgreementMember" name="RocheCollaborationPralsetnibAgreementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_LicenseMilestoneMember" name="LicenseMilestoneMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTransactionPrice" name="CollaborativeArrangementTransactionPrice" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementTransactionPriceUpfrontPayment" name="CollaborativeArrangementTransactionPriceUpfrontPayment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementTransactionPriceStockIssuedPremiumOnSaleOfStockToCounterparty" name="CollaborativeArrangementTransactionPriceStockIssuedPremiumOnSaleOfStockToCounterparty" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementMilestonesContingentPaymentsEligibleToReceive" name="CollaborativeArrangementMilestonesContingentPaymentsEligibleToReceive" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMilestonesSpecifiedRegulatoryAndCommercializationMilestonesAchieved" name="CollaborativeArrangementMilestonesSpecifiedRegulatoryAndCommercializationMilestonesAchieved" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedEntity" name="CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedEntity" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedCounterparty" name="CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedCounterparty" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementUpfrontPaymentCashPaymentReceived" name="CollaborativeArrangementUpfrontPaymentCashPaymentReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementMilestonesCashPaymentsReceived" name="CollaborativeArrangementMilestonesCashPaymentsReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementInventoryPurchasedByCounterparty" name="CollaborativeArrangementInventoryPurchasedByCounterparty" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMaterialPromisesNumber" name="CollaborativeArrangementMaterialPromisesNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_RevenuePerformanceObligationPerformanceObligationsNumber" name="RevenuePerformanceObligationPerformanceObligationsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMaterialComponentsNumber" name="CollaborativeArrangementMaterialComponentsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementLicensedProductTermFromFirstCommercialSale" name="CollaborativeArrangementLicensedProductTermFromFirstCommercialSale" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementLicenseOptionRightsNumber" name="CollaborativeArrangementLicenseOptionRightsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsWithExclusiveCommercializationRightsNumber" name="CollaborativeArrangementCollaborationProgramsWithExclusiveCommercializationRightsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriod" name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InventoryCurrentAndNoncurrentNet" name="InventoryCurrentAndNoncurrentNet" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InventoryCurrentAndNoncurrentWorkInProcessNetOfReserves" name="InventoryCurrentAndNoncurrentWorkInProcessNetOfReserves" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InventoryCurrentAndNoncurrentFinishedGoodsNetOfReserves" name="InventoryCurrentAndNoncurrentFinishedGoodsNetOfReserves" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ScheduleOfInventoryCurrentAndNoncurrentTableTextBlock" name="ScheduleOfInventoryCurrentAndNoncurrentTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMilestonesAchieved" name="CollaborativeArrangementMilestonesAchieved" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <xsd:element name="InventoryCurrentAndNoncurrentRawMaterialsNetOfReserves" id="bpmc_InventoryCurrentAndNoncurrentRawMaterialsNetOfReserves" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CollaborativeArrangementCommercializationReductionInSellingGeneralAndAdministrativeExpenses" id="bpmc_CollaborativeArrangementCommercializationReductionInSellingGeneralAndAdministrativeExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ZaiLabShanghaiCoLtdMember" id="bpmc_ZaiLabShanghaiCoLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementMaterialPromisesCombinedIntoDistinctPerformanceObligationNumber" id="bpmc_CollaborativeArrangementMaterialPromisesCombinedIntoDistinctPerformanceObligationNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDate" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDate" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenAfterFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenAfterFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenPriorToFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenPriorToFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="TerritorySpecificActivitiesManufacturingServicesAndRoyaltyMember" id="bpmc_TerritorySpecificActivitiesManufacturingServicesAndRoyaltyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExternalResearchDevelopmentAndCommercialContractCosts" id="bpmc_ExternalResearchDevelopmentAndCommercialContractCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtSecuritiesAvailableForSaleCreditRelatedImpairmentsCharges" id="bpmc_DebtSecuritiesAvailableForSaleCreditRelatedImpairmentsCharges" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CollaborativeArrangementUpfrontPayment" id="bpmc_CollaborativeArrangementUpfrontPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementMilestonesPotentialContingentPayments" id="bpmc_CollaborativeArrangementMilestonesPotentialContingentPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SixthStreetPartnersFinancingAgreementMember" id="bpmc_SixthStreetPartnersFinancingAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SixthStreetPartnersFinancingAgreementSeniorSecuredTermLoanFacilityMember" id="bpmc_SixthStreetPartnersFinancingAgreementSeniorSecuredTermLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SixthStreetPartnersFinancingAgreementSeniorSecuredDelayedDrawTermLoanFacilityMember" id="bpmc_SixthStreetPartnersFinancingAgreementSeniorSecuredDelayedDrawTermLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SixthStreetPartnersFinancingAgreementIncrementalTermLoanMember" id="bpmc_SixthStreetPartnersFinancingAgreementIncrementalTermLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentTranchesNumber" id="bpmc_DebtInstrumentTranchesNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentVariableRateFloor" id="bpmc_DebtInstrumentVariableRateFloor" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SixthStreetPartnersFinancingAgreementSeniorSecuredTermLoanFacilitiesMember" id="bpmc_SixthStreetPartnersFinancingAgreementSeniorSecuredTermLoanFacilitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RoyaltyPharmaRoyaltyPurchaseAgreementMember" id="bpmc_RoyaltyPharmaRoyaltyPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesPercentageRate" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesPercentageRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedPercentageIncrease" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedPercentageIncrease" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesAmountMaximum" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesAmountMaximum" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalAmount" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedAmount" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRatio" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedRatio" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="SixthStreetPartnersMember" id="bpmc_SixthStreetPartnersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TerritorySpecificActivitiesMember" id="bpmc_TerritorySpecificActivitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentFaceAmountPotentialAmount" id="bpmc_DebtInstrumentFaceAmountPotentialAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentCovenantsConsolidatedLiquidityPeriodCommencingFromDateTermLoanFundedToDateDayBeforeNextTermLoansFundedEachDayThereafter" id="bpmc_DebtInstrumentCovenantsConsolidatedLiquidityPeriodCommencingFromDateTermLoanFundedToDateDayBeforeNextTermLoansFundedEachDayThereafter" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NoncashInterestExpense" id="bpmc_NoncashInterestExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IdrxIncMember" id="bpmc_IdrxIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborationAndLicenseMember" id="bpmc_CollaborationAndLicenseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SaleOfFutureRoyaltiesAndRevenuesMember" id="bpmc_SaleOfFutureRoyaltiesAndRevenuesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SixthStreetPartnersFutureRevenuePurchaseAgreementMember" id="bpmc_SixthStreetPartnersFutureRevenuePurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentTransactionsNumber" id="bpmc_DebtInstrumentTransactionsNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="SixthStreetPartnersFinancingArrangementsMember" id="bpmc_SixthStreetPartnersFinancingArrangementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EquitySecuritiesWithoutReadilyDeterminableFairValueLicenseAgreementSharesReceived" id="bpmc_EquitySecuritiesWithoutReadilyDeterminableFairValueLicenseAgreementSharesReceived" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="EquitySecuritiesWithoutReadilyDeterminableFairValueTransactionCosts" id="bpmc_EquitySecuritiesWithoutReadilyDeterminableFairValueTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardTargetAwardGrantsUltimatelyEarnPercentage" id="bpmc_ShareBasedCompensationArrangementByShareBasedPaymentAwardTargetAwardGrantsUltimatelyEarnPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPerformanceMetricCumulativeRelativeTotalShareholderReturnPeriod" id="bpmc_ShareBasedCompensationArrangementByShareBasedPaymentAwardPerformanceMetricCumulativeRelativeTotalShareholderReturnPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementJointlyResearchAndAdvanceNovelProteinDegraderTherapiesIntoDevelopmentCandidatesNumber" id="bpmc_CollaborativeArrangementJointlyResearchAndAdvanceNovelProteinDegraderTherapiesIntoDevelopmentCandidatesNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ScheduleOfProceedsFromMaturitiesOfDebtSecuritiesAvailableForSaleTableTextBlock" id="bpmc_ScheduleOfProceedsFromMaturitiesOfDebtSecuritiesAvailableForSaleTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="JeffereyWAlbersMember" id="bpmc_JeffereyWAlbersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ChristopherMurrayMember" id="bpmc_ChristopherMurrayMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CustomerOneMember" id="bpmc_CustomerOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CustomerTwoMember" id="bpmc_CustomerTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CustomerThreeMember" id="bpmc_CustomerThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CustomerFourMember" id="bpmc_CustomerFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SharesIssuedSharesShareBasedPaymentArrangementIncludingEmployeeStockPurchasePlan" id="bpmc_SharesIssuedSharesShareBasedPaymentArrangementIncludingEmployeeStockPurchasePlan" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SharesIssuedValueShareBasedPaymentArrangementIncludingEmployeeStockPurchasePlan" id="bpmc_SharesIssuedValueShareBasedPaymentArrangementIncludingEmployeeStockPurchasePlan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ArielHurleyMember" id="bpmc_ArielHurleyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementGlobalDevelopmentActivitiesIncreaseReductionInResearchAndDevelopmentExpenses" id="bpmc_CollaborativeArrangementGlobalDevelopmentActivitiesIncreaseReductionInResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="VantaiMember" id="bpmc_VantaiMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MichaelLandsittelMember" id="bpmc_MichaelLandsittelMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ValuationAllowancesAndReservesProductRevenueMember" id="bpmc_ValuationAllowancesAndReservesProductRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtReacquisitionLiabilityCurrent" id="bpmc_DebtReacquisitionLiabilityCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SaleOfStockAuthorizedAmount" id="bpmc_SaleOfStockAuthorizedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ClinicalManufacturingAgreementsMember" id="bpmc_ClinicalManufacturingAgreementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LBeckerHewesMember" id="bpmc_LBeckerHewesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebraDursoBumpusMember" id="bpmc_DebraDursoBumpusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="GavretoProfitShareInUnitedStatesOfAmericaMember" id="bpmc_GavretoProfitShareInUnitedStatesOfAmericaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RigelPharmaceuticalsIncMember" id="bpmc_RigelPharmaceuticalsIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AssetPurchaseAgreementPurchasePriceReceivable" id="bpmc_AssetPurchaseAgreementPurchasePriceReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AssetPurchaseAgreementPurchasePriceReceivablePayableUponFirstCommercialSale" id="bpmc_AssetPurchaseAgreementPurchasePriceReceivablePayableUponFirstCommercialSale" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AssetPurchaseAgreementPurchasePriceReceivableAdditionalContingentAmountPayable" id="bpmc_AssetPurchaseAgreementPurchasePriceReceivableAdditionalContingentAmountPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AssetPurchaseAgreementContingentSpecifiedRegulatoryAndCommercialMilestonePayments" id="bpmc_AssetPurchaseAgreementContingentSpecifiedRegulatoryAndCommercialMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AssetPurchaseAgreementTieredPercentageRoyaltiesOnAnnualNetSalesLowEndOfRange" id="bpmc_AssetPurchaseAgreementTieredPercentageRoyaltiesOnAnnualNetSalesLowEndOfRange" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="AssetPurchaseAgreementTieredPercentageRoyaltiesOnAnnualNetSalesHighEndOfRange" id="bpmc_AssetPurchaseAgreementTieredPercentageRoyaltiesOnAnnualNetSalesHighEndOfRange" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ArrangementOtherThanCollaborativeAssetPurchaseAgreementMember" id="bpmc_ArrangementOtherThanCollaborativeAssetPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SixthStreetPartnersFinancingAgreementSeniorSecuredDelayedDrawTermLoanFacilitySecondDrawMember" id="bpmc_SixthStreetPartnersFinancingAgreementSeniorSecuredDelayedDrawTermLoanFacilitySecondDrawMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CustomerFiveMember" id="bpmc_CustomerFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="StockIncentivePlan2024Member" id="bpmc_StockIncentivePlan2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementTransactionPriceInventory" id="bpmc_CollaborativeArrangementTransactionPriceInventory" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CollaborativeArrangementTransactionPriceMilestoneAndRoyaltyPayments" id="bpmc_CollaborativeArrangementTransactionPriceMilestoneAndRoyaltyPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="GavretoPerformanceObligationRightsInUnitedStatesOfAmericaMember" id="bpmc_GavretoPerformanceObligationRightsInUnitedStatesOfAmericaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="GavretoProductConsiderationMember" id="bpmc_GavretoProductConsiderationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEquityInstrumentsOtherThanOptionsOutstandingNumber" id="bpmc_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEquityInstrumentsOtherThanOptionsOutstandingNumber" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
</xsd:schema>
