Cover [Abstract] Document Information [Table] Document Information [Line Items] Entity Central Index Key Document Type Document Quarterly Report Document Period End Date Document Transition Report Entity File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, City or Town Entity Address, State or Province Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company Entity Shell Company Entity Listing, Par Value Per Share Entity Common Stock, Shares Outstanding Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Period Focus Amendment Flag Statement of Financial Position [Abstract] Statement [Table] Statement [Line Items] Assets [Abstract] Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Cash and cash equivalents Available-for-sale Securities, Debt Securities, Current Investments, available-for-sale Accounts Receivable, Net, Current Accounts receivable, net Represents the current amount of unbilled accounts receivable, including reimbursable research and development costs. Unbilled Receivables Including Reimbursable Costs Current Unbilled accounts receivable Inventory, Net Inventory Total Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Assets, Current Total current assets Available-for-sale Securities, Debt Securities, Noncurrent Investments, available-for-sale Property, Plant and Equipment, Net Property and equipment, net Total Operating lease right-of-use assets, net Operating lease right-of-use assets, net Restricted Cash, Noncurrent Restricted cash Other Assets, Noncurrent Other assets Total assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Accrued Liabilities, Current Accrued expenses Total Current portion of operating lease liabilities Current portion of operating lease liabilities Contract with Customer, Liability, Current Current portion of deferred revenue Total current liabilities Total current liabilities Operating lease liabilities, net of current portion Operating lease liabilities, net of current portion Contract with Customer, Liability, Noncurrent Deferred revenue, net of current portion Other Liabilities, Noncurrent Other long-term liabilities Total liabilities Total liabilities Commitments and Contingencies Commitments (Note 15) Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Outstanding Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued and outstanding Common Stock, Value, Issued Common stock, $0.001 par value; 120,000,000 shares authorized; 54,284,501 and 49,272,223 shares issued and outstanding at June 30, 2020 and December 31, 2019, respectively Additional Paid in Capital Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders' Equity Attributable to Parent Ending Balance Beginning Balance Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Number of Shares, Par Value and Other Disclosures [Abstract] Preferred Stock Disclosures Preferred Stock, Par or Stated Value Per Share Preferred stock, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred stock, shares authorized (in shares) Preferred Stock, Shares Issued Preferred stock, shares issued (in shares) Preferred Stock, Shares Outstanding Preferred stock, shares outstanding (in shares) Common Stock, Number of Shares, Par Value and Other Disclosures [Abstract] Common Stock Disclosures Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, shares authorized (in shares) Common Stock, Shares, Issued Ending Balance (in shares) Beginning Balance (in shares) Common stock, shares issued (in shares) Common Stock, Shares, Outstanding Common Stock, shares outstanding (in shares) Income Statement [Abstract] Revenues [Abstract] Revenues Revenues: Revenue from Contract with Customer, Including Assessed Tax Collaboration revenue Total CStone collaboration revenue Total revenues Operating Expenses [Abstract] Cost and operating expenses: Cost of Goods and Services Sold Cost of sales Research and Development Expense Research and development Selling, General and Administrative Expense Selling, general and administrative Costs and Expenses Total cost and operating expenses Nonoperating Income (Expense) [Abstract] Other income (expense): Interest Income (Expense), Net Interest income, net Other Nonoperating Income (Expense) Other income, net Nonoperating Income (Expense) Total other income Net Income (Loss) Attributable to Parent Net loss Net loss Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive loss: Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Unrealized gain (losses) on available-for-sale investments Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax Currency translation adjustments Cumulative translation adjustment Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Earnings Per Share, Basic and Diluted Net loss per share - basic and diluted Weighted Average Number of Shares Outstanding, Basic and Diluted Weighted-average number of common shares used in net loss per share - basic and diluted Statement of Stockholders' Equity [Abstract] Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Common Stock [Member] Common Stock Additional Paid In Capital [Member] Additional Paid-In Capital Accumulated Other Comprehensive Income [Member] Accumulated Other Comprehensive Loss Retained Earnings [Member] Accumulated Deficit Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures Issuance of common stock under stock plan Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures Issuance of common stock under stock plan (in shares) Stock Issued During Period, Value, Employee Stock Purchase Plan Purchase of common stock under ESPP Stock Issued During Period, Shares, Employee Stock Purchase Plans ESPP shares issued during period (in shares) Purchase of common stock under ESPP (in shares) Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation expense Stock Issued During Period, Value, New Issues Follow on offering, net of issuance costs Stock Issued During Period, Shares, New Issues Stock purchase agreement issued and sold Follow on offering, net of issuance costs (in shares) Other Comprehensive Income (Loss), Securities, Available-for-sale, Adjustment, before Tax Unrealized gain (loss) on available-for-sale securities Adjustments to Additional Paid in Capital, Other Other Statement of Cash Flows [Abstract] Net Cash Provided by (Used in) Operating Activities [Abstract] Cash flows from operating activities Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net loss Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation, Depletion and Amortization Depreciation and amortization Lease, Right-of-Use Asset, Amortization. Lease, Right-of-Use Asset, Amortization Noncash lease expense Share-based Compensation Stock-based compensation The cash inflow from the accretion of premiums and discounts on investments. Accretion Of Premiums And Discounts On Investments Accretion of premiums and discounts on investments Other Operating Activities, Cash Flow Statement Other Increase (Decrease) in Operating Capital [Abstract] Changes in assets and liabilities: Increase (Decrease) in Accounts Receivable Accounts receivable The increase (decrease) during the reporting period of the amount of customer assets. Increase (Decrease) in Customer Assets Unbilled accounts receivable Increase (Decrease) in Inventories Inventory Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Increase (Decrease) in Other Noncurrent Assets Other assets Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities Accrued expenses Increase (Decrease) in Contract with Customer, Liability Deferred revenue The increase (decrease) during the reporting period in the aggregate amount of operating lease liabilities incurred. Increase (Decrease) in Operating Lease Liabilities Operating lease liabilities Net Cash Provided by (Used in) Operating Activities Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities [Abstract] Cash flows from investing activities Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Payments to Acquire Available-for-sale Securities, Debt Purchases of investments Proceeds from Maturities, Prepayments and Calls of Available-for-sale Securities Maturities of investments Net Cash Provided by (Used in) Investing Activities Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Financing Activities [Abstract] Cash flows from financing activities Proceeds from Issuance Initial Public Offering Proceeds from public offerings of common stock, net of issuance cost Proceeds from Stock Options Exercised Net proceeds from stock option exercises and employee stock purchase plan Payments of Stock Issuance Costs Payment of offering costs Other financing activities Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Net increase in cash, cash equivalents, and restricted cash Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash, cash equivalents and restricted cash at end of period Cash, cash equivalents and restricted cash at beginning of period Total cash, cash equivalents, and restricted cash shown in condensed consolidated statements of cash flows Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Effect of exchange rate changes on cash, cash equivalents and restricted cash Supplemental Cash Flow Information [Abstract] Supplemental cash flow information Represents the future cash outflow to pay stock issuance costs that have occurred in a noncash or partial noncash transaction. Stock Issuance Costs Incurred but Not yet Paid Noncash Or Partial Noncash Transaction Public offering costs incurred but unpaid at period end Capital Expenditures Incurred but Not yet Paid Property and equipment purchases unpaid at period end Income Taxes Paid, Net Cash paid for taxes, net Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents [Abstract] Reconciliation of cash, cash equivalents, and restricted cash Organization, Consolidation and Presentation of Financial Statements [Abstract] Disclosure Text Block [Abstract] Disclosure Text Block Nature of Operations [Text Block] Nature of Business Accounting Policies [Abstract] Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block] Summary of Significant Accounting Policies and Recent Accounting Pronouncements Investments and Cash [Abstract] Cash, Cash Equivalents, and Marketable Securities [Text Block] Cash Equivalents and Investments Fair Value Disclosures [Abstract] Fair Value Disclosures [Text Block] Fair Value of Financial Instruments Revenue from Contract with Customer [Abstract] Allowance for Credit Losses [Text Block] Product Revenue Reserves and Allowances Inventory Disclosure [Abstract] Inventory Disclosure [Text Block] Inventory Restricted Cash and Cash Equivalents [Abstract] Restricted Assets Disclosure [Text Block] Restricted Cash Property, Plant and Equipment [Abstract] Property, Plant and Equipment Disclosure [Text Block] Property and Equipment, Net Payables and Accruals [Abstract] Accounts Payable and Accrued Liabilities Disclosure [Text Block] Accrued Expenses Collaborative Arrangement Disclosure [Abstract] Collaborative Arrangement Disclosure [Abstract] Collaborative Arrangement Disclosure [Text Block] Collaboration and License Agreements Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock-based Compensation Earnings Per Share [Abstract] Earnings Per Share [Text Block] Net Loss per Share Income Tax Disclosure [Abstract] Income Tax Disclosure [Text Block] Income Taxes Leases [Abstract] Lessee, Operating Leases [Text Block] Leases Commitments and Contingencies Disclosure [Abstract] Commitments Disclosure [Text Block] Commitments Subsequent Events [Abstract] Subsequent Events [Text Block] Subsequent Events Policy Text Block [Abstract] Policy Text Blocks Basis of Accounting, Policy [Policy Text Block] Basis of Presentation Use of Estimates, Policy [Policy Text Block] Use of Estimates Disclosure of significant accounting policies. Significant Accounting Policy [Policy Text Block] Significant Accounting Policies Revenue from Contract with Customer [Policy Text Block] Product Revenue Receivables, Trade and Other Accounts Receivable, Allowance for Doubtful Accounts, Policy [Policy Text Block] Accounts Receivable, net Inventory, Policy [Policy Text Block] Inventory New Accounting Pronouncements, Policy [Policy Text Block] New Accounting Pronouncements Disclosure of accounting policy for reclassification. Reclassifications Policy Policy [Text Block] Reclassification Table Text Block [Abstract] Table Text Blocks Cash, Cash Equivalents and Investments [Table Text Block] Schedule of cash equivalents and investments, available-for-sale Fair Value Measurements, Recurring and Nonrecurring [Table Text Block] Schedule of financial instruments measured at fair value Contract with Customer, Asset, Allowance for Credit Loss [Table Text Block] Schedule of product revenue allowance and reserve categories Schedule of Inventory, Current [Table Text Block] Schedule of capitalized inventory Property, Plant and Equipment [Table Text Block] Schedule of property and equipment Schedule of Accrued Liabilities [Table Text Block] Schedule of accrued expenses Tabular disclosure of manufacturing services related to the global development activities. Schedule Of Manufacturing Services Related To Agreement Activities [Table Text Block] Summary of manufacturing and research and development services related to the global development activities Disaggregation of Revenue [Table Text Block] Summary of revenue recognized Contract with Customer, Asset and Liability [Table Text Block] Summary of receivables Share-based Compensation, Stock Options, Activity [Table Text Block] Summary of stock option activity Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] Summary of restricted stock units activity Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Summary of stock-based compensation expense, allocation by type of awards and recognition in statements of operations Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Schedule of common stock equivalents excluded from calculation of diluted net loss per share applicable to common stockholders Lease, Cost [Table Text Block] Summary of lease expenses and cash flow and weighted average information Cash, Cash Equivalents, and Short-term Investments [Abstract] Cash, cash equivalents and investments Cash, Cash Equivalents, and Short-term Investments Cash, cash equivalents and investments Accounting Standards Update and Change in Accounting Principle [Table] New Accounting Pronouncements or Change in Accounting Principle [Line Items] Summary of Significant Accounting Policies and Recent Accounting Pronouncements Change in Accounting Principle, Accounting Standards Update, Adopted [true false] Change in Accounting Principle, Accounting Standards Update, Adopted Change in Accounting Principle, Accounting Standards Update, Adoption Date Change in Accounting Principle, Accounting Standards Update, Adoption Date Change in Accounting Principle, Accounting Standards Update, Early Adoption [true false] Change in Accounting Principle, Accounting Standards Update, Early Adoption Schedule of Cash and Cash Equivalents [Table] Cash and Cash Equivalents [Line Items] Cash and Cash Equivalents [Abstract] Cash equivalents: Cash Equivalents, at Carrying Value Cash equivalents, Amortized Cost Cash and Cash Equivalents, Fair Value Disclosure Cash equivalents Investment Income [Table] Net Investment Income [Line Items] Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract] Investments, available-for-sale: Available-for-sale Debt Securities, Amortized Cost Basis Available-for-sale, Amortized Cost Available-for-sale Debt Securities, Accumulated Gross Unrealized Gain, before Tax Available-for-sale, Unrealized Gain Available-for-sale Debt Securities, Accumulated Gross Unrealized Loss, before Tax Available-for-sale, Unrealized Losses Available-for-sale Securities, Debt Securities Investments, available-for-sale Investments [Abstract] Cash Equivalents and Investments Represents the cost of cash equivalents and cost of debt securities, which are categorized neither as held-to-maturity nor trading, net of adjustments including accretion, amortization, collection of cash, previous other-than-temporary impairments recognized in earnings (less any cumulative-effect adjustments recognized, as defined), and fair value hedge accounting adjustments, if any. Cash Equivalent and Available-for-sale Debt Securities, Amortized Cost Basis Total, Amortized Cost Cash Equivalents and Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Cash Equivalents and Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Total, Unrealized Gain Cash Equivalents and Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Cash Equivalents and Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Total, Unrealized Losses Represents the fair value of cash equivalents and amount of debt securities categorized neither as held-to-maturity nor trading. Cash Equivalents and Available-for-sale Securities, Debt Securities, Fair Value Total, Fair Value Available-for-sale, Securities in Unrealized Loss Positions, Qualitative Disclosure, Number of Positions [Abstract] Unrealized loss position, number of positions Debt Securities, Available-for-sale, Unrealized Loss Position, Number of Positions Number of held securities in an unrealized loss position Available-for-sale Securities, Continuous Unrealized Loss Position, Accumulated Loss [Abstract] Unrealized loss position, aggregate fair value Debt Securities, Available-for-sale, Unrealized Loss Position, Accumulated Loss Unrealized loss position Debt Securities, Available-for-sale, Maturity, Fair Value, Rolling Maturity [Abstract] Investments, available-for-sale Number of investments in debt securities measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). Debt Securities, Available-for-sale, Number of Positions Securities with remaining maturities greater than one year Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Rolling after One Through Five Years, Fair Value Aggregate fair value with remaining maturities greater than one year Fair Value Measurements, Recurring and Nonrecurring [Table] Measurement Frequency [Axis] Fair Value Measurement Frequency [Domain] Fair Value, Measurement Frequency [Domain] Fair Value Measurements Recurring [Member] Recurring Fair Value, Hierarchy [Axis] Fair Value Measurements Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Fair Value Inputs Level1 [Member] Active Markets (Level 1) Fair Value Inputs Level2 [Member] Observable Inputs (Level 2) Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Net Asset (Liability) [Abstract] Fair Value of Financial Instruments Assets, Fair Value Disclosure Total Disaggregation of Revenue [Table] Disaggregation of Revenue [Line Items] Contract with Customer, Asset, Allowance for Credit Loss [Roll Forward] Product revenue allowance Contract with Customer, Asset, Allowance for Credit Loss Ending balance Beginning balance Product revenue allowance Contract with Customer, Asset, Credit Loss Expense (Reversal) Provision related to sales in the current period Contract with Customer, Asset, Allowance for Credit Loss, Recovery Credits and payments made Contract with Customer, Asset, after Allowance for Credit Loss [Abstract] Product revenue allowance Inventory, Net [Abstract] Inventory Inventory, Work in Process, Net of Reserves Work in process Inventory, Finished Goods, Net of Reserves Finished goods Inventory Write-down Inventory write-down Restricted Cash [Abstract] Restricted Cash Restricted Cash Restricted cash Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Property, Plant and Equipment [Line Items] Property, Plant and Equipment, Net [Abstract] Property and Equipment, Net Property, Plant and Equipment, Useful Life Estimated Useful Life (Years) Property, Plant and Equipment, Estimated Useful Lives Estimated Useful Life Property, Plant and Equipment, Gross Gross property and equipment Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Less: accumulated depreciation and amortization Depreciation [Abstract] Depreciation expense Depreciation expense Accrued Liabilities, Current [Abstract] Accrued Expenses External Research, Development and Commercial Contract Costs, Current External Research, Development and Commercial Contract Costs, Current Research, development and commercial contract costs Employee-related Liabilities, Current Employee compensation Accrued Professional Fees, Current Accrued professional fees Amount of accrued accumulated credit loss for right to consideration in exchange for good or service transferred to customer when right is conditioned on something other than passage of time. Accrued Contract With Customer Asset Accumulated Allowance For Credit Loss Revenue-related reserves Other Accrued Liabilities, Current Other Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Collaboration Agreements Collaboration Agreements Non-refundable upfront payment received by the reporting entity from the collaborative partner. Nonrefundable Upfront Payment Received Non-refundable upfront payment received Collaboration Agreement, Cash Milestone Payments Received Collaboration Agreement, Cash Milestone Payments Received Milestone payment received Collaborative Arrangement Eligible Milestone Payments. Collaborative Arrangement Eligible Milestone Payments Eligible milestone payments The amount of cash milestone payments due to be received by the company. Collaboration Agreement, Cash Milestone Payments Due Cash milestone payment The amount of other payments and potential development, regulatory and sales-based milestone payments for licensed products, due to be received by the company. Collaboration Agreement, Milestone And Other Payments Milestone other payment The amount of purchase of manufacturing inventory under the collaboration agreement. Collaboration Agreement, Purchase Of Manufacturing Inventory Purchase specified manufacturing inventory Number of performance obligations under the collaboration agreement. Collaboration Agreement, Number Of Performance Obligations Number of performance obligations The amount of purchase of existing manufacturing inventory under the collaboration agreement. Collaboration Agreement, Purchase Of Existing Manufacturing Inventory Purchase of existing manufacturing inventory The amount of purchase of in-progress manufacturing inventory under the collaboration agreement. Collaboration Agreement, Purchase Of In Progress Manufacturing Inventory Purchase of in-process manufacturing inventory Licensed Product Term From First Commercial Sale. Licensed Product Term From First Commercial Sale Licensed product term from first commercial sale The number of material components. Number of Materials Components Number of materials components The number of small molecule therapeutics targeting kinases. Number Of Small Molecule Therapeutics Targeting Kinases Number of small molecule therapeutics targeting kinases Represents the number of license option rights to obtain an exclusive license to exploit products derived from the collaboration programs. Number Of License Option Rights Number of option rights to obtain exclusive license Represents the number of collaboration programs. Number Of Collaboration Programs Number of potential collaboration programs Number of Milestones Acheived Number of Milestones Acheived Number of milestones acheived The number of material promises. Number of Material Promises Number of material promises Represents the number of collaboration programs with exclusive commercialization rights for licensed products. Number Of Collaboration Programs With Exclusive Commercialization Rights Number of collaboration programs with exclusive commercialization rights for licensed products Initial Cash Payment Per Collaboration Agreement. Initial Cash Payment Per Collaboration Agreement Initial cash payment Contract with Customer, Liability Deferred revenue Represents the number of collaboration programs in which the entity will retain commercialization rights in the United States for the licensed products, and counterparty will receive commercialization rights outside of the United States for the licensed products. Number Of Collaboration Programs With Specified Commercialization Rights Number of collaboration programs with specified commercial rights for each party Represents the aggregate amount of eligible contingent option fees and milestone payments related to specified research, pre-clinical, clinical, regulatory and sales-based milestones. Collaborative Arrangement Eligible Contingent Option Fees And Milestone Payments Total eligible contingent option fees and milestone payments Eligible contingent option and milestone payments Represents the amount of option fees and milestone payments for research, pre-clinical and clinical development events prior to licensing across all five potential collaboration programs, including contingent milestone payments for initiation of each of the collaboration programs for which the parties will work together to select targets (pre-option exercise milestones). Collaborative Arrangement Eligible Option Fees And Milestone Payments Prior To Licensing Across All Programs Eligible option fees and milestones prior to licensing for all potential collaboration programs The period of time for which written notice is required to be received from the collaborative partner prior to termination of the collaborative agreement. Collaborative Arrangement Period Of Prior Notice To Terminate Agreement Written termination notice period Represents the cash inflow from achieved research milestone payment received, which will be recognized as revenue over the period of performance. Achieved Research Milestone Payment Received To Be Recognized Over Performance Period Achieved research milestone payment received which will be recognized over period of performance Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period Research and development services, performance period Contract with Customer, Liability, Revenue Recognized Revenue recognized, change in contract liability Amounts included in the contact liability at the beginning of the period Manufacturing Services Related To Agreement Activities. Manufacturing Services Related To Agreement Activities Manufacturing and research and development services related to global development activities Manufacturing services related to territory-specific activities License Milestone Revenue. License Milestone Revenue License milestone revenue Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Plan Name [Axis] Plan Name [Domain] Plan Name [Domain] Represents the stock option and incentive plan approved in 2015. Stock Option And Incentive Plan2015 [Member] 2015 Stock Option and Incentive Plan Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award, Additional General Disclosures [Abstract] Stock-based compensation Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Initial shares of common stock authorized for issuance of stock awards (in shares) The percentage of additional shares authorized for issuance under an established share-based compensation plan. Share-based Compensation Arrangement by Share-based Payment Award, Percentage of Additional Shares Authorized Increase in number of shares available for grant (as a percent) Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized Increase in number of shares available for grant Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Number of shares available for grant Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Outstanding at end of period (in shares) Outstanding at beginning of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercised (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Other Increases (Decreases) in Period Cancelled (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Weighted-Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Outstanding at end of period (in dollars per share) Outstanding at beginning of period (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Granted (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Exercised (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Other Share Increase (Decrease) in Period, Weighted Average Exercise Price Cancelled (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract] Additional disclosures Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number Shares - Exercisable (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price Weighted-Average Exercise Price - Exercisable (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Shares Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Unvested at end of period (in shares) Unvested at beginning of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Vested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Weighted-Average Grant Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Unvested at end of period (in dollars per share) Unvested at beginning or period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Granted (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Vested (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Forfeited (in dollars per share) Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized [Abstract] Stock-based compensation Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Total unrecognized compensation cost related to non-vested stock awards Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options Total unrecognized compensation cost related to non-vested stock option awards Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition Weighted-average period over which unrecognized compensation cost will be recognized Share-based Compensation Arrangement by Share-based Payment Award, Options, and Equity Instruments Other than Options, Grants in Period Share-based Compensation Arrangement by Share-based Payment Award, Options, and Equity Instruments Other than Options, Grants in Period Shares granted (in shares) Common Stock, Capital Shares Reserved for Future Issuance Number of common shares reserved for future issuance (in shares) Represents the annual cumulative increase for common stock issuance, as a percentage of the number of shares of common stock issued and outstanding. Annual Cumulative Increase Percentage of Number of Share of Common Stock Issued and Outstanding Annual increase for common stock for issuance (as a percent) Increase in aggregate number of common shares reserved for future issuance. Common Stock Increase Capital Shares Reserved for Future Issuance Increase of common shares reserved for future issuance (in shares) Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] Employee Service Share-based Compensation, Aggregate Disclosures [Abstract] Total stock based compensation expense Share-based Payment Arrangement, Expensed and Capitalized, Amount Subtotal Share-based Payment Arrangement, Amount Capitalized Capitalized stock-based compensation costs Allocated Share-based Compensation Expense Total Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract] Antidilutive securities excluded from computation of earnings per share Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Antidilutive securities excluded from computation of earnings per share Effective Income Tax Rate Reconciliation, Percent [Abstract] Income Taxes Duration of operating loss carrybacks under the Coronavirus Aid Relief And Economic Security Act. Coronavirus Aid Relief And Economic Security Act Carryback Net Operating Losses Period CARES net operating losses carryback period Taxable income limitation percentage that was eliminated under the Coronavirus Aid Relief And Economic Security Act. Coronavirus Aid Relief And Economic Security Act Taxable Income Limitation Percentage Eliminated CARES eliminated taxable income limitation percentage The interest deductible percentage of adjusted taxable income. Interest Deductible Percentage Of Adjusted Taxable Income Deductible interest percentage limitation The interest deductible percentage of adjusted taxable income under the Tax Cuts And Jobs Act 2017. Tax Cuts And Jobs Act 2017 Interest Deductible Percentage Of Adjusted Taxable Income Tax Cuts and Jobs Act of 2017 deductible interest percentage limitation Charitable deduction limitation percentage under the Coronavirus Aid Relief And Economic Security Act. Coronavirus Aid Relief And Economic Security Act Charitable Deduction Limitation Percentage CARES charitable deduction limit percentage Qualified improvement property recovery period under the Coronavirus Aid Relief And Economic Security Act. Coronavirus Aid Relief And Economic Security Act Qualified Improvement Property Recovery Period CARES qualified improvement property recovery period Bonus depreciation percentage under the Coronavirus Aid Relief And Economic Security Act. Coronavirus Aid Relief And Economic Security Act Bonus Depreciation Percentage CARES bonus depreciation percentage Lessee, Lease, Description [Table] Lessee, Lease, Description [Line Items] Lessee, Operating Lease, Description [Abstract] Leases Lessee, Operating Lease, Remaining Lease Term Operating lease remaining lease term Operating leases cost: Operating Lease, Cost Lease cost Sublease Income Sublease income Lease, Cost Net lease cost Cash Flow, Operating Activities, Lessee [Abstract] Leases Operating lease liabilities Cash paid for amounts included in the measurement of lease liabilities, operating cash flows from operating leases Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Lease liabilities arising from obtaining right-of-use assets, operating leases Lessee Disclosure [Abstract] Leases Operating Lease, Weighted Average Remaining Lease Term Weighted average remaining lease term in years Operating Lease, Weighted Average Discount Rate, Percent Weighted average discount rate Purchase Obligation, Fiscal Year Maturity [Abstract] Commitments Purchase Obligation Manufacturing purchase obligations Subsequent Event [Table] Subsequent Event [Line Items] Subsequent Events The amount of upfront cash payment receivable under the collaboration agreement. Collaboration Agreement, Upfront Cash Payments Receivable Upfront cash payment receivable Share Price Purchase price Collaboration Agreement, Percentage of Global Development Costs Shared, Entity Collaboration Agreement, Percentage of Global Development Costs Shared, Entity Percentage of global development costs, Company (as a percent) Collaboration Agreement, Percentage of Global Development Costs Shared, Counterparty Collaboration Agreement, Percentage of Global Development Costs Shared, Counterparty Percentage of global development costs, Roche (as a percent) Shares Issued, Price Per Share Private placement purchase price Proceeds from Issuance of Private Placement Gross proceeds from issuance of private placement Number of shares agreed to be issued or sold under the share purchase agreement in private placement. Private Placement, Shares Agreed To Be Issued Or Sold Number of shares agreed to be issued or sold under the share purchase agreement The amount of share proceeds that will be received on issuance of additional shares in private placement under share repurchase agreement. Private Placement, Additional Share Proceeds To Be Received Additional gross proceeds to expiration or termination Product and Service [Axis] Products And Services [Domain] Product and Service [Domain] Product [Member] Product revenue, net Collaboration [Member] Collaboration [Member] Collaboration revenue Accounting Standards Update [Axis] Type Of Adoption [Member] Accounting Standards Update [Domain] New Accounting Pronouncement [Member] Adjustments for New Accounting Pronouncement [Member] Accounting Standards Update201613 [Member] Accounting Standards Update 2016-13 Accounting Standards Update201813 [Member] Accounting Standards Update 2018-13 Accounting Standards Update201818 [Member] Accounting Standards Update 2018-18 Accounting Standards Update201815 [Member] Accounting Standards Update 2018-15 Accounting Standards Update201912 [Member] Accounting Standards Update 2019-12 Cash and Cash Equivalents [Axis] Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member] Cash and Cash Equivalents [Domain] Cash Equivalents [Member] Cash Equivalents [Member] Money Market Funds [Member] Money market funds U S Treasury Securities [Member] U.S. Treasury obligations Investment Type [Axis] Investment Type Categorization [Member] Investments [Domain] U S Government Corporations And Agencies Securities [Member] U.S. government agency securities Fair Value Inputs Level12 And3 [Member] Fair Value, Inputs, Level 1, 2 and 3 [Member] Balance Sheet Location [Axis] Balance Sheet Location [Domain] Balance Sheet Location [Domain] Accounts Receivable [Member] Accounts Receivable, Net Accrued Liabilities [Member] Accrued Expenses Long-Lived Tangible Asset [Axis] Property Plant And Equipment Type [Domain] Property, Plant and Equipment, Type [Domain] Equipment [Member] Lab equipment Furniture And Fixtures [Member] Furniture and fixtures Computer Equipment [Member] Computer equipment Leasehold Improvements [Member] Leasehold improvements Software And Software Development Costs [Member] Software Construction In Progress [Member] Construction-in-progress Type of Arrangement and Non-arrangement Transactions [Axis] Arrangements And Nonarrangement Transactions [Member] Arrangements and Non-arrangement Transactions [Domain] Collaborative Arrangement [Member] Collaboration Counterparty Name [Axis] Repurchase Agreement Counterparty Name [Domain] Counterparty Name [Domain] Clementia [Member] Clementia [Member] Clementia C Stone [Member] C Stone [Member] C Stone Represent information pertaining to Roche. Roche [Member] Roche Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Research And Development Arrangement Contract To Perform For Others Type [Domain] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] License Agreement Terms [Member] License Agreement Terms [Member] Represents information pertaining to the agreement terms prior to exercise license right option under research and development arrangements. Prior To Exercise License Right Option [Member] Prior To Exercise License Right Option Represents information pertaining to the agreement terms of exercise of license option under research and development arrangements. Exercise Of License Right Option [Member] Exercise Of License Right Option Represents information pertaining to the agreement terms of exercise of license option, where product has not been commercially sold under research and development arrangements. Exercise Of License Option Product Not Commercially Sold [Member] Exercise Of License Option Product Not Commercially Sold Represents information pertaining to the agreement terms of exercise of license option, where product has been commercially sold under research and development arrangements. Exercise Of License Option Product Commercially Sold [Member] Exercise Of License Option Product Commercially Sold Information by categories of milestones. Milestone [Axis] Different categories of milestones. Milestone [Domain] Milestone [Domain] Development and Regulatory Milestones. Development And Regulatory Milestones [Member] Development and regulatory milestones Sales Based Milestones. Sales Based Milestones [Member] Sales-based milestones Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Subsequent Event [Member] Subsequent Event Collaborative Arrangement Global Development Of Licensed product [Member] Collaborative Arrangement Global Development Of Licensed Product [Member] Global development of the licensed product Award Type [Axis] Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain] Equity Award [Domain] Restricted Stock Units R S U [Member] Restricted stock units Inducement Plan, 2020 [Member] Inducement Plan2020 [Member] 2020 Inducement Plan Employee Stock [Member] Employee Stock Employee Stock Option [Member] Stock Options Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Research And Development Expense [Member] Research and development General And Administrative Expense [Member] General and administrative Antidilutive Securities [Axis] Antidilutive Securities Name [Domain] Antidilutive Securities, Name [Domain] Range [Axis] Range [Member] Range [Domain] Minimum [Member] Minimum Maximum [Member] Maximum Sale of Stock [Axis] Sale Of Stock Name Of Transaction [Domain] Sale of Stock [Domain] Private Placement [Member] Private Placement