<?xml version="1.0" encoding="us-ascii"?>
<!--XBRL document created with Toppan Merrill Bridge  10.2.0.4 -->
<!--Based on XBRL 2.1-->
<!--Created on: 2/16/2023 9:35:23 PM-->
<!--Modified on: 2/16/2023 9:35:23 PM-->
<xsd:schema targetNamespace="http://www.blueprintmedicines.com/20221231" attributeFormDefault="unqualified" elementFormDefault="qualified" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:ref="http://www.xbrl.org/2006/ref" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:us-gaap="http://fasb.org/us-gaap/2022" xmlns:us-types="http://fasb.org/us-types/2022" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:srt-types="http://fasb.org/srt-types/2022" xmlns:bpmc="http://www.blueprintmedicines.com/20221231" xmlns:enum2="http://xbrl.org/2020/extensible-enumerations-2.0" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2020-01-21" xmlns:currency="http://xbrl.sec.gov/currency/2022" xmlns:us-roles="http://fasb.org/us-roles/2022" xmlns:sic="http://xbrl.sec.gov/sic/2022" xmlns:srt-roles="http://fasb.org/srt-roles/2022" xmlns:stpr="http://xbrl.sec.gov/stpr/2022" xmlns:utr="http://www.xbrl.org/2009/utr" xmlns:exch="http://xbrl.sec.gov/exch/2022" xmlns:naics="http://xbrl.sec.gov/naics/2022" xmlns:country="http://xbrl.sec.gov/country/2022" xmlns:attributeFormDefault="unqualified" xmlns:srt="http://fasb.org/srt/2022" xmlns:deprecated="http://www.xbrl.org/2009/role/deprecated" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:dei="http://xbrl.sec.gov/dei/2022" xmlns:dtr="http://www.xbrl.org/2009/dtr" xmlns:cef="http://xbrl.sec.gov/cef/2022" xmlns:xbrldi="http://xbrl.org/2006/xbrldi">
  <xsd:annotation>
    <xsd:appinfo>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStandardAndCustomAxisDomainDefaults" id="DisclosureStandardAndCustomAxisDomainDefaults">
        <link:definition>99900 - Disclosure - Standard And Custom Axis Domain Defaults</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/StatementConsolidatedBalanceSheets" id="StatementConsolidatedBalanceSheets">
        <link:definition>00100 - Statement - Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/StatementConsolidatedStatementsOfOperationsAndComprehensiveLoss" id="StatementConsolidatedStatementsOfOperationsAndComprehensiveLoss">
        <link:definition>00200 - Statement - Consolidated Statements of Operations and Comprehensive Loss</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/StatementConsolidatedStatementsOfCashFlows" id="StatementConsolidatedStatementsOfCashFlows">
        <link:definition>00400 - Statement - Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/StatementConsolidatedStatementsOfCashFlowsParenthetical" id="StatementConsolidatedStatementsOfCashFlowsParenthetical">
        <link:definition>00405 - Statement - Consolidated Statements of Cash Flows (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFinancingArrangementsEstimatedTotalGrossPaymentsDetails" id="DisclosureFinancingArrangementsEstimatedTotalGrossPaymentsDetails">
        <link:definition>40305 - Disclosure - Financing Arrangements - Estimated Total Gross Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureAcquisitionConsiderationTransferredDetails" id="DisclosureAcquisitionConsiderationTransferredDetails">
        <link:definition>40402 - Disclosure - Acquisition - Consideration Transferred (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureAcquisitionIdentifiableNetAssetsAcquiredDetails" id="DisclosureAcquisitionIdentifiableNetAssetsAcquiredDetails">
        <link:definition>40405 - Disclosure - Acquisition - Identifiable Net Assets Acquired (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureMarketableSecuritiesTabularDisclosureDetails" id="DisclosureMarketableSecuritiesTabularDisclosureDetails">
        <link:definition>40501 - Disclosure - Marketable Securities - Tabular Disclosure (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureMarketableSecuritiesMaturitiesDetails" id="DisclosureMarketableSecuritiesMaturitiesDetails">
        <link:definition>40504 - Disclosure - Marketable Securities - Maturities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFairValueOfFinancialInstrumentsDetails" id="DisclosureFairValueOfFinancialInstrumentsDetails">
        <link:definition>40601 - Disclosure - Fair Value of Financial Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureInventoryCapitalizedDetails" id="DisclosureInventoryCapitalizedDetails">
        <link:definition>40801 - Disclosure - Inventory - Capitalized (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureInventoryBalanceSheetClassificationDetails" id="DisclosureInventoryBalanceSheetClassificationDetails">
        <link:definition>40802 - Disclosure - Inventory - Balance Sheet Classification (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosurePropertyAndEquipmentNetPropertyAndEquipmentAndRelatedAccumulatedDepreciationDetails" id="DisclosurePropertyAndEquipmentNetPropertyAndEquipmentAndRelatedAccumulatedDepreciationDetails">
        <link:definition>41002 - Disclosure - Property and Equipment, Net - Property and Equipment and Related Accumulated Depreciation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureAccruedExpensesDetails" id="DisclosureAccruedExpensesDetails">
        <link:definition>41101 - Disclosure - Accrued Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsTransactionPriceDetails" id="DisclosureCollaborationAndLicenseAgreementsTransactionPriceDetails">
        <link:definition>41202 - Disclosure - Collaboration and License Agreements - Transaction Price (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsSaleOfStockDetails" id="DisclosureCollaborationAndLicenseAgreementsSaleOfStockDetails">
        <link:definition>41204 - Disclosure - Collaboration and License Agreements - Sale of Stock (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsContractAssetsAndLiabilitiesDetails" id="DisclosureCollaborationAndLicenseAgreementsContractAssetsAndLiabilitiesDetails">
        <link:definition>41210 - Disclosure - Collaboration and License Agreements - Contract Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationStockBasedCompensationExpenseByTypeDetails" id="DisclosureStockBasedCompensationStockBasedCompensationExpenseByTypeDetails">
        <link:definition>41304 - Disclosure - Stock-based Compensation - Stock-based Compensation Expense - By Type (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureNetIncomeLossPerShareNetIncomeLossPerShareDetails" id="DisclosureNetIncomeLossPerShareNetIncomeLossPerShareDetails">
        <link:definition>41401 - Disclosure - Net Income (Loss) Per Share - Net Income (Loss) Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureIncomeTaxesReconciliationDetails" id="DisclosureIncomeTaxesReconciliationDetails">
        <link:definition>41501 - Disclosure - Income Taxes - Reconciliation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureIncomeTaxesDeferredTaxAssetsAndLiabilitiesDetails" id="DisclosureIncomeTaxesDeferredTaxAssetsAndLiabilitiesDetails">
        <link:definition>41502 - Disclosure - Income Taxes - Deferred Tax Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureLeasesComponentsOfLeaseExpenseDetails" id="DisclosureLeasesComponentsOfLeaseExpenseDetails">
        <link:definition>41602 - Disclosure - Leases - Components of Lease Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureLeasesFutureMinimumLeasePaymentsDetails" id="DisclosureLeasesFutureMinimumLeasePaymentsDetails">
        <link:definition>41605 - Disclosure - Leases - Future Minimum Lease Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureLeasesTotalLeaseLiabilityDetails" id="DisclosureLeasesTotalLeaseLiabilityDetails">
        <link:definition>41606 - Disclosure - Leases - Total Lease Liability (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureEmployeeBenefitPlansSwitzerlandDefinedBenefitPlanTabularDisclosureDetails" id="DisclosureEmployeeBenefitPlansSwitzerlandDefinedBenefitPlanTabularDisclosureDetails">
        <link:definition>41702 - Disclosure - Employee Benefit Plans - Switzerland Defined Benefit Plan - Tabular Disclosure (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DocumentDocumentAndEntityInformation" id="DocumentDocumentAndEntityInformation">
        <link:definition>00090 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/StatementConsolidatedBalanceSheetsParenthetical" id="StatementConsolidatedBalanceSheetsParenthetical">
        <link:definition>00105 - Statement - Consolidated Balance Sheets (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/StatementConsolidatedStatementsOfStockholdersEquity" id="StatementConsolidatedStatementsOfStockholdersEquity">
        <link:definition>00300 - Statement - Consolidated Statements of Stockholders' Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureNatureOfBusiness" id="DisclosureNatureOfBusiness">
        <link:definition>10101 - Disclosure - Nature of Business</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncements" id="DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncements">
        <link:definition>10201 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureMarketableSecurities" id="DisclosureMarketableSecurities">
        <link:definition>10501 - Disclosure - Marketable Securities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFairValueOfFinancialInstruments" id="DisclosureFairValueOfFinancialInstruments">
        <link:definition>10601 - Disclosure - Fair Value of Financial Instruments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureProductRevenueReservesAndAllowances" id="DisclosureProductRevenueReservesAndAllowances">
        <link:definition>10701 - Disclosure - Product Revenue Reserves and Allowances</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureInventory" id="DisclosureInventory">
        <link:definition>10801 - Disclosure - Inventory</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureRestrictedCash" id="DisclosureRestrictedCash">
        <link:definition>10901 - Disclosure - Restricted Cash</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosurePropertyAndEquipmentNet" id="DisclosurePropertyAndEquipmentNet">
        <link:definition>11001 - Disclosure - Property and Equipment, Net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureAccruedExpenses" id="DisclosureAccruedExpenses">
        <link:definition>11101 - Disclosure - Accrued Expenses</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreements" id="DisclosureCollaborationAndLicenseAgreements">
        <link:definition>11201 - Disclosure - Collaboration and License Agreements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensation" id="DisclosureStockBasedCompensation">
        <link:definition>11301 - Disclosure - Stock-based Compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureNetLossPerShare" id="DisclosureNetLossPerShare">
        <link:definition>11401 - Disclosure - Net Loss Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureIncomeTaxes" id="DisclosureIncomeTaxes">
        <link:definition>11501 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureEmployeeBenefitPlans" id="DisclosureEmployeeBenefitPlans">
        <link:definition>11701 - Disclosure - Employee Benefit Plans</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCommitmentsAndContingencies" id="DisclosureCommitmentsAndContingencies">
        <link:definition>11801 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureSubsequentEvents" id="DisclosureSubsequentEvents">
        <link:definition>11901 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsPolicies" id="DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsPolicies">
        <link:definition>20202 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFinancingArrangementsTables" id="DisclosureFinancingArrangementsTables">
        <link:definition>30303 - Disclosure - Financing Arrangements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureMarketableSecuritiesTables" id="DisclosureMarketableSecuritiesTables">
        <link:definition>30503 - Disclosure - Marketable Securities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFairValueOfFinancialInstrumentsTables" id="DisclosureFairValueOfFinancialInstrumentsTables">
        <link:definition>30603 - Disclosure - Fair Value of Financial Instruments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureProductRevenueReservesAndAllowancesTables" id="DisclosureProductRevenueReservesAndAllowancesTables">
        <link:definition>30703 - Disclosure - Product Revenue Reserves and Allowances (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureInventoryTables" id="DisclosureInventoryTables">
        <link:definition>30803 - Disclosure - Inventory (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosurePropertyAndEquipmentNetTables" id="DisclosurePropertyAndEquipmentNetTables">
        <link:definition>31003 - Disclosure - Property and Equipment, Net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureAccruedExpensesTables" id="DisclosureAccruedExpensesTables">
        <link:definition>31103 - Disclosure - Accrued Expenses (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsTables" id="DisclosureCollaborationAndLicenseAgreementsTables">
        <link:definition>31203 - Disclosure - Collaboration and License Agreements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationTables" id="DisclosureStockBasedCompensationTables">
        <link:definition>31303 - Disclosure - Stock-based Compensation (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureNetLossPerShareTables" id="DisclosureNetLossPerShareTables">
        <link:definition>31403 - Disclosure - Net Loss Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureIncomeTaxesTables" id="DisclosureIncomeTaxesTables">
        <link:definition>31503 - Disclosure - Income Taxes (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsImpairmentOfLongLivedAssetsDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsImpairmentOfLongLivedAssetsDetails">
        <link:definition>40203 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Impairment of Long-Lived Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsStockBasedCompensationExpenseDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsStockBasedCompensationExpenseDetails">
        <link:definition>40204 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Stock-Based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsSegmentAndGeographicInformationDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsSegmentAndGeographicInformationDetails">
        <link:definition>40205 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Segment and Geographic Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFinancingArrangementsGeneralInformationDetails" id="DisclosureFinancingArrangementsGeneralInformationDetails">
        <link:definition>40301 - Disclosure - Financing Arrangements - General Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFinancingArrangementsRoyaltyAndSalesInformationDetails" id="DisclosureFinancingArrangementsRoyaltyAndSalesInformationDetails">
        <link:definition>40302 - Disclosure - Financing Arrangements - Royalty and Sales Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFinancingArrangementsLongTermDebtDetails" id="DisclosureFinancingArrangementsLongTermDebtDetails">
        <link:definition>40303 - Disclosure - Financing Arrangements - Long-term Debt (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFinancingArrangementsRollForwardDetails" id="DisclosureFinancingArrangementsRollForwardDetails">
        <link:definition>40304 - Disclosure - Financing Arrangements - Roll Forward (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureAcquisitionGeneralInformationDetails" id="DisclosureAcquisitionGeneralInformationDetails">
        <link:definition>40401 - Disclosure - Acquisition - General Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureAcquisitionAcquiredIntellectualPropertyDetails" id="DisclosureAcquisitionAcquiredIntellectualPropertyDetails">
        <link:definition>40403 - Disclosure - Acquisition - Acquired Intellectual Property (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureAcquisitionPurchasePriceDetails" id="DisclosureAcquisitionPurchasePriceDetails">
        <link:definition>40404 - Disclosure - Acquisition - Purchase Price (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureProductRevenueReservesAndAllowancesProductRevenueDetails" id="DisclosureProductRevenueReservesAndAllowancesProductRevenueDetails">
        <link:definition>40701 - Disclosure - Product Revenue Reserves and Allowances - Product Revenue (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureProductRevenueReservesAndAllowancesConcentrationRiskDetails" id="DisclosureProductRevenueReservesAndAllowancesConcentrationRiskDetails">
        <link:definition>40702 - Disclosure - Product Revenue Reserves and Allowances - Concentration Risk (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureProductRevenueReservesAndAllowancesRevenueRelatedReservesDetails" id="DisclosureProductRevenueReservesAndAllowancesRevenueRelatedReservesDetails">
        <link:definition>40704 - Disclosure - Product Revenue Reserves and Allowances - Revenue-related Reserves (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureInventoryWriteDownDetails" id="DisclosureInventoryWriteDownDetails">
        <link:definition>40803 - Disclosure - Inventory - Write-down (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosurePropertyAndEquipmentNetEstimatedUsefulLivesDetails" id="DisclosurePropertyAndEquipmentNetEstimatedUsefulLivesDetails">
        <link:definition>41001 - Disclosure - Property and Equipment, Net - Estimated Useful Lives (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosurePropertyAndEquipmentNetDepreciationExpenseDetails" id="DisclosurePropertyAndEquipmentNetDepreciationExpenseDetails">
        <link:definition>41003 - Disclosure - Property and Equipment, Net - Depreciation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsGeneralInformationDetails" id="DisclosureCollaborationAndLicenseAgreementsGeneralInformationDetails">
        <link:definition>41201 - Disclosure - Collaboration and License Agreements - General Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsEquityInvestmentDetails" id="DisclosureCollaborationAndLicenseAgreementsEquityInvestmentDetails">
        <link:definition>41203 - Disclosure - Collaboration and License Agreements - Equity Investment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsManufacturingAndResearchAndDevelopmentServicesDetails" id="DisclosureCollaborationAndLicenseAgreementsManufacturingAndResearchAndDevelopmentServicesDetails">
        <link:definition>41205 - Disclosure - Collaboration and License Agreements - Manufacturing and Research and Development Services (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsRevenueRecognizedDetails" id="DisclosureCollaborationAndLicenseAgreementsRevenueRecognizedDetails">
        <link:definition>41206 - Disclosure - Collaboration and License Agreements - Revenue Recognized (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsCollaborationLossSharingDetails" id="DisclosureCollaborationAndLicenseAgreementsCollaborationLossSharingDetails">
        <link:definition>41207 - Disclosure - Collaboration and License Agreements - Collaboration Loss Sharing (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsReductionInExpensesDetails" id="DisclosureCollaborationAndLicenseAgreementsReductionInExpensesDetails">
        <link:definition>41208 - Disclosure - Collaboration and License Agreements - Reduction in Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsChangeInContractWithCustomerLiabilityDetails" id="DisclosureCollaborationAndLicenseAgreementsChangeInContractWithCustomerLiabilityDetails">
        <link:definition>41209 - Disclosure - Collaboration and License Agreements - Change in Contract with Customer, Liability (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsPerformanceObligationsDetails" id="DisclosureCollaborationAndLicenseAgreementsPerformanceObligationsDetails">
        <link:definition>41211 - Disclosure - Collaboration and License Agreements - Performance Obligations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCollaborationAndLicenseAgreementsPerformanceObligationsDefaultDetails" id="DisclosureCollaborationAndLicenseAgreementsPerformanceObligationsDefaultDetails">
        <link:definition>41211 - Disclosure - Collaboration and License Agreements - Performance Obligations Default (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensation2015StockOptionAndIncentivePlanDetails" id="DisclosureStockBasedCompensation2015StockOptionAndIncentivePlanDetails">
        <link:definition>41301 - Disclosure - Stock-based Compensation - 2015 Stock Option and Incentive Plan (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensation2020InducementPlanDetails" id="DisclosureStockBasedCompensation2020InducementPlanDetails">
        <link:definition>41302 - Disclosure - Stock-based Compensation - 2020 Inducement Plan (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationStockBasedCompensationExpenseByClassificationDetails" id="DisclosureStockBasedCompensationStockBasedCompensationExpenseByClassificationDetails">
        <link:definition>41305 - Disclosure - Stock-based Compensation - Stock-based Compensation Expense - By Classification (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationUnrecognizedCompensationCostsDetails" id="DisclosureStockBasedCompensationUnrecognizedCompensationCostsDetails">
        <link:definition>41306 - Disclosure - Stock-based Compensation - Unrecognized Compensation Costs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationAwardsGeneralInformationDetails" id="DisclosureStockBasedCompensationAwardsGeneralInformationDetails">
        <link:definition>41307 - Disclosure - Stock-based Compensation - Awards - General Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationStockOptionsWeightedAverageAssumptionsDetails" id="DisclosureStockBasedCompensationStockOptionsWeightedAverageAssumptionsDetails">
        <link:definition>41308 - Disclosure - Stock-based Compensation - Stock Options - Weighted Average Assumptions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationRestrictedStockUnitsActivityDetails" id="DisclosureStockBasedCompensationRestrictedStockUnitsActivityDetails">
        <link:definition>41311 - Disclosure - Stock-based Compensation - Restricted Stock Units - Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationRestrictedStockUnitsAdditionalInformationDetails" id="DisclosureStockBasedCompensationRestrictedStockUnitsAdditionalInformationDetails">
        <link:definition>41312 - Disclosure - Stock-based Compensation - Restricted Stock Units - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationEmployeeStockPurchasePlanDetails" id="DisclosureStockBasedCompensationEmployeeStockPurchasePlanDetails">
        <link:definition>41313 - Disclosure - Stock-based Compensation - Employee Stock Purchase Plan (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureNetIncomeLossPerShareAntiDilutiveSecuritiesDetails" id="DisclosureNetIncomeLossPerShareAntiDilutiveSecuritiesDetails">
        <link:definition>41402 - Disclosure - Net Income (Loss) Per Share - Anti-dilutive Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureIncomeTaxesValuationAllowanceDetails" id="DisclosureIncomeTaxesValuationAllowanceDetails">
        <link:definition>41503 - Disclosure - Income Taxes - Valuation Allowance (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureIncomeTaxesNetOperatingLossCarryforwardsDetails" id="DisclosureIncomeTaxesNetOperatingLossCarryforwardsDetails">
        <link:definition>41504 - Disclosure - Income Taxes - Net Operating Loss Carryforwards (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureIncomeTaxesTaxCreditCarryforwardsDetails" id="DisclosureIncomeTaxesTaxCreditCarryforwardsDetails">
        <link:definition>41505 - Disclosure - Income Taxes - Tax Credit Carryforwards (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureIncomeTaxesUncertainTaxPositionsDetails" id="DisclosureIncomeTaxesUncertainTaxPositionsDetails">
        <link:definition>41506 - Disclosure - Income Taxes - Uncertain Tax Positions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureIncomeTaxesFinancingArrangementsDetails" id="DisclosureIncomeTaxesFinancingArrangementsDetails">
        <link:definition>41507 - Disclosure - Income Taxes - Financing Arrangements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureIncomeTaxesEquityInvestmentDetails" id="DisclosureIncomeTaxesEquityInvestmentDetails">
        <link:definition>41508 - Disclosure - Income Taxes - Equity Investment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureLeasesGeneralInformationDetails" id="DisclosureLeasesGeneralInformationDetails">
        <link:definition>41601 - Disclosure - Leases - General Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCommitmentsAndContingenciesPurchaseCommitmentsDetails" id="DisclosureCommitmentsAndContingenciesPurchaseCommitmentsDetails">
        <link:definition>41801 - Disclosure - Commitments and Contingencies - Purchase Commitments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureCommitmentsAndContingenciesIndemnificationAgreementsDetails" id="DisclosureCommitmentsAndContingenciesIndemnificationAgreementsDetails">
        <link:definition>41802 - Disclosure - Commitments and Contingencies - Indemnification Agreements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureSubsequentEventsDetails" id="DisclosureSubsequentEventsDetails">
        <link:definition>41901 - Disclosure - Subsequent Events (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFinancingArrangements" id="DisclosureFinancingArrangements">
        <link:definition>10301 - Disclosure - Financing Arrangements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureAcquisition" id="DisclosureAcquisition">
        <link:definition>10401 - Disclosure - Acquisition</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureLeases" id="DisclosureLeases">
        <link:definition>11601 - Disclosure - Leases</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureAcquisitionTables" id="DisclosureAcquisitionTables">
        <link:definition>30403 - Disclosure - Acquisition (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureLeasesTables" id="DisclosureLeasesTables">
        <link:definition>31603 - Disclosure - Leases (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureEmployeeBenefitPlansTables" id="DisclosureEmployeeBenefitPlansTables">
        <link:definition>31703 - Disclosure - Employee Benefit Plans (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureNatureOfBusinessDetails" id="DisclosureNatureOfBusinessDetails">
        <link:definition>40101 - Disclosure - Nature of Business (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsAccountsReceivableNetDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsAccountsReceivableNetDetails">
        <link:definition>40201 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Accounts Receivable, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsSellingGeneralAndAdministrativeExpensesDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesAndRecentAccountingPronouncementsSellingGeneralAndAdministrativeExpensesDetails">
        <link:definition>40202 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Selling, General and Administrative Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureFinancingArrangementsAdditionalInformationDetails" id="DisclosureFinancingArrangementsAdditionalInformationDetails">
        <link:definition>40306 - Disclosure - Financing Arrangements - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureMarketableSecuritiesUnrealizedLossPositionDetails" id="DisclosureMarketableSecuritiesUnrealizedLossPositionDetails">
        <link:definition>40502 - Disclosure - Marketable Securities - Unrealized Loss Position (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureMarketableSecuritiesImpairmentDetails" id="DisclosureMarketableSecuritiesImpairmentDetails">
        <link:definition>40503 - Disclosure - Marketable Securities - Impairment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureMarketableSecuritiesProceedsFromMaturitiesDetails" id="DisclosureMarketableSecuritiesProceedsFromMaturitiesDetails">
        <link:definition>40505 - Disclosure - Marketable Securities - Proceeds from Maturities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureMarketableSecuritiesRealizedGainsLossesDetails" id="DisclosureMarketableSecuritiesRealizedGainsLossesDetails">
        <link:definition>40506 - Disclosure - Marketable Securities - Realized Gains (Losses) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureProductRevenueReservesAndAllowancesProductRevenueAllowanceAndReserveDetails" id="DisclosureProductRevenueReservesAndAllowancesProductRevenueAllowanceAndReserveDetails">
        <link:definition>40703 - Disclosure - Product Revenue Reserves and Allowances - Product Revenue Allowance and Reserve (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureRestrictedCashDetails" id="DisclosureRestrictedCashDetails">
        <link:definition>40901 - Disclosure - Restricted Cash (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationStockBasedCompensationExpenseGeneralInformationDetails" id="DisclosureStockBasedCompensationStockBasedCompensationExpenseGeneralInformationDetails">
        <link:definition>41303 - Disclosure - Stock-based Compensation - Stock-based Compensation Expense - General Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationStockOptionsActivityDetails" id="DisclosureStockBasedCompensationStockOptionsActivityDetails">
        <link:definition>41309 - Disclosure - Stock-based Compensation - Stock Options - Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureStockBasedCompensationStockOptionsAdditionalInformationDetails" id="DisclosureStockBasedCompensationStockOptionsAdditionalInformationDetails">
        <link:definition>41310 - Disclosure - Stock-based Compensation - Stock Options - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureLeasesCashFlowInformationDetails" id="DisclosureLeasesCashFlowInformationDetails">
        <link:definition>41603 - Disclosure - Leases - Cash Flow Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureLeasesWeightedAverageRemainingLeaseTermAndWeightedAverageDiscountRateDetails" id="DisclosureLeasesWeightedAverageRemainingLeaseTermAndWeightedAverageDiscountRateDetails">
        <link:definition>41604 - Disclosure - Leases - Weighted Average Remaining Lease-term and Weighted Average Discount Rate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureEmployeeBenefitPlans401KSavingsPlanDetails" id="DisclosureEmployeeBenefitPlans401KSavingsPlanDetails">
        <link:definition>41701 - Disclosure - Employee Benefit Plans - 401(k) Savings Plan (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.blueprintmedicines.com/role/DisclosureEmployeeBenefitPlansSwitzerlandDefinedBenefitPlanGeneralInformationDetails" id="DisclosureEmployeeBenefitPlansSwitzerlandDefinedBenefitPlanGeneralInformationDetails">
        <link:definition>41703 - Disclosure - Employee Benefit Plans - Switzerland Defined Benefit Plan - General Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:type="simple" xlink:href="bpmc-20221231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="bpmc-20221231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="bpmc-20221231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="bpmc-20221231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Calculation Links, all" />
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:import namespace="http://xbrl.sec.gov/dei/2022" schemaLocation="https://xbrl.sec.gov/dei/2022/dei-2022.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/2020-01-21" schemaLocation="https://www.xbrl.org/dtr/type/2020-01-21/types.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <import namespace="http://fasb.org/us-roles/2022" schemaLocation="https://xbrl.fasb.org/us-gaap/2022/elts/us-roles-2022.xsd" xmlns="http://www.w3.org/2001/XMLSchema" />
  <import namespace="http://fasb.org/us-gaap/2022" schemaLocation="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd" xmlns="http://www.w3.org/2001/XMLSchema" />
  <import namespace="http://fasb.org/srt/2022" schemaLocation="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd" xmlns="http://www.w3.org/2001/XMLSchema" />
  <import namespace="http://xbrl.sec.gov/country/2022" schemaLocation="https://xbrl.sec.gov/country/2022/country-2022.xsd" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementDisclosureAbstract" name="CollaborativeArrangementDisclosureAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardCliffVestingPeriodForNewEmployees" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardCliffVestingPeriodForNewEmployees" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAdditionalSharesAuthorized" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAdditionalSharesAuthorized" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_StockOptionAndIncentivePlan2015Member" name="StockOptionAndIncentivePlan2015Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OperatingLeasesBaseAnnualRentInitial" name="OperatingLeasesBaseAnnualRentInitial" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OperatingLeasesBaseAnnualRentMaximum" name="OperatingLeasesBaseAnnualRentMaximum" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OperatingLeasesAllowanceForLeaseholdImprovements" name="OperatingLeasesAllowanceForLeaseholdImprovements" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_UnbilledReceivablesIncludingReimbursableCostsCurrent" name="UnbilledReceivablesIncludingReimbursableCostsCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_AnnualCumulativeIncreasePercentageOfNumberOfShareOfCommonStockIssuedAndOutstanding" name="AnnualCumulativeIncreasePercentageOfNumberOfShareOfCommonStockIssuedAndOutstanding" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CommonStockIncreaseCapitalSharesReservedForFutureIssuance" name="CommonStockIncreaseCapitalSharesReservedForFutureIssuance" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_AccretionOfPremiumsAndDiscountsOnInvestments" name="AccretionOfPremiumsAndDiscountsOnInvestments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_RocheMember" name="RocheMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_EffectiveIncomeTaxRateReconciliationTaxCreditGeneralBusinessPercent" name="EffectiveIncomeTaxRateReconciliationTaxCreditGeneralBusinessPercent" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OfficeAndLaboratorySpaceInCambridgeMassachusetts38SidneyStreetAnd45SidneyStreetMember" name="OfficeAndLaboratorySpaceInCambridgeMassachusetts38SidneyStreetAnd45SidneyStreetMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_IncreaseDecreaseInCustomerAssets" name="IncreaseDecreaseInCustomerAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CStoneMember" name="CStoneMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OfficeAndLaboratorySpaceInCambridgeMassachusettsMember" name="OfficeAndLaboratorySpaceInCambridgeMassachusettsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OfficeAndLaboratorySpaceInCambridgeMassachusetts45SidneyStreetMember" name="OfficeAndLaboratorySpaceInCambridgeMassachusetts45SidneyStreetMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OfficeAndLaboratorySpaceInCambridgeMassachusetts45SidneyStreetExpansionPremisesMember" name="OfficeAndLaboratorySpaceInCambridgeMassachusetts45SidneyStreetExpansionPremisesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ProceedsFromIssuanceOfCommonStockNetOfUnderwritingDiscountsCommissionsAndOfferingExpenses" name="ProceedsFromIssuanceOfCommonStockNetOfUnderwritingDiscountsCommissionsAndOfferingExpenses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_NetProceedsFromStockOptionExercisesAndEmployeeStockPurchasePlan" name="NetProceedsFromStockOptionExercisesAndEmployeeStockPurchasePlan" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ScheduleOfManufacturingServicesRelatedToAgreementActivitiesTableTextBlock" name="ScheduleOfManufacturingServicesRelatedToAgreementActivitiesTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ClementiaMember" name="ClementiaMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_LeaseRightOfUseAssetAmortization" name="LeaseRightOfUseAssetAmortization" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_DeferredTaxLiabilitiesRightOfUseAssets" name="DeferredTaxLiabilitiesRightOfUseAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborationMember" name="CollaborationMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InducementPlan2020Member" name="InducementPlan2020Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ContractWithCustomerAssetAllowanceForCreditLossPriorPeriodIncreaseDecrease" name="ContractWithCustomerAssetAllowanceForCreditLossPriorPeriodIncreaseDecrease" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_AccruedContractWithCustomerAssetAccumulatedAllowanceForCreditLoss" name="AccruedContractWithCustomerAssetAccumulatedAllowanceForCreditLoss" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ExternalResearchDevelopmentAndCommercialContractCostsCurrent" name="ExternalResearchDevelopmentAndCommercialContractCostsCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborationProfitLossSharing" name="CollaborationProfitLossSharing" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_StockIssuedDuringPeriodValueNewIssuesPremium" name="StockIssuedDuringPeriodValueNewIssuesPremium" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_StockIssuedDuringPeriodValueNewIssuesPurchaseConsideration" name="StockIssuedDuringPeriodValueNewIssuesPurchaseConsideration" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ManufacturingAgreementOctober2020Member" name="ManufacturingAgreementOctober2020Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_RocheCollaborationAndLicenseImmunotherapyAgreementMember" name="RocheCollaborationAndLicenseImmunotherapyAgreementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_RocheCollaborationPralsetnibAgreementMember" name="RocheCollaborationPralsetnibAgreementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_LicenseMilestoneMember" name="LicenseMilestoneMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_UpfrontLicenseMember" name="UpfrontLicenseMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTransactionPrice" name="CollaborativeArrangementTransactionPrice" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementTransactionPriceUpfrontPayment" name="CollaborativeArrangementTransactionPriceUpfrontPayment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementTransactionPriceInventoryPurchasedByCounterpartyInProcessManufacturingInventory" name="CollaborativeArrangementTransactionPriceInventoryPurchasedByCounterpartyInProcessManufacturingInventory" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementTransactionPriceStockIssuedPremiumOnSaleOfStockToCounterparty" name="CollaborativeArrangementTransactionPriceStockIssuedPremiumOnSaleOfStockToCounterparty" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementMilestonesContingentPaymentsEligibleToReceive" name="CollaborativeArrangementMilestonesContingentPaymentsEligibleToReceive" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMilestonesSpecifiedRegulatoryAndCommercializationMilestonesAchieved" name="CollaborativeArrangementMilestonesSpecifiedRegulatoryAndCommercializationMilestonesAchieved" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedEntity" name="CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedEntity" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedCounterparty" name="CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedCounterparty" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementUpfrontPaymentCashPaymentReceived" name="CollaborativeArrangementUpfrontPaymentCashPaymentReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementMilestonesCashPaymentsReceived" name="CollaborativeArrangementMilestonesCashPaymentsReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementInventoryPurchasedByCounterparty" name="CollaborativeArrangementInventoryPurchasedByCounterparty" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMaterialPromisesNumber" name="CollaborativeArrangementMaterialPromisesNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_RevenuePerformanceObligationPerformanceObligationsNumber" name="RevenuePerformanceObligationPerformanceObligationsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMaterialComponentsNumber" name="CollaborativeArrangementMaterialComponentsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementLicensedProductTermFromFirstCommercialSale" name="CollaborativeArrangementLicensedProductTermFromFirstCommercialSale" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementLicenseOptionRightsNumber" name="CollaborativeArrangementLicenseOptionRightsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsWithExclusiveCommercializationRightsNumber" name="CollaborativeArrangementCollaborationProgramsWithExclusiveCommercializationRightsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsNumber" name="CollaborativeArrangementCollaborationProgramsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementOptionFeesAndMilestonesPreClinicalAndClinicalDevelopmentEventsPriorToLicensingContingentPaymentsEligibleToReceive" name="CollaborativeArrangementOptionFeesAndMilestonesPreClinicalAndClinicalDevelopmentEventsPriorToLicensingContingentPaymentsEligibleToReceive" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriod" name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveNotBeenCommerciallySold" name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveNotBeenCommerciallySold" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveBeenCommerciallySold" name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveBeenCommerciallySold" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMilestonesResearchMilestonesAchieved" name="CollaborativeArrangementMilestonesResearchMilestonesAchieved" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementManufacturingAndResearchAndDevelopmentServicesRelatedToGlobalDevelopmentActivitiesNetOfCostSharingPayments" name="CollaborativeArrangementManufacturingAndResearchAndDevelopmentServicesRelatedToGlobalDevelopmentActivitiesNetOfCostSharingPayments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_InventoryCurrentAndNoncurrentNet" name="InventoryCurrentAndNoncurrentNet" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InventoryCurrentAndNoncurrentWorkInProcessNetOfReserves" name="InventoryCurrentAndNoncurrentWorkInProcessNetOfReserves" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InventoryCurrentAndNoncurrentFinishedGoodsNetOfReserves" name="InventoryCurrentAndNoncurrentFinishedGoodsNetOfReserves" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ScheduleOfInventoryCurrentAndNoncurrentTableTextBlock" name="ScheduleOfInventoryCurrentAndNoncurrentTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_FollowOnPublicOfferingAndAtMarketOfferingMember" name="FollowOnPublicOfferingAndAtMarketOfferingMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OperatingLossCarryforwardsUnlimitedCarryforward" name="OperatingLossCarryforwardsUnlimitedCarryforward" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_OperatingLossCarryforwardsLimitationsOnUseAvailableForUtilization" name="OperatingLossCarryforwardsLimitationsOnUseAvailableForUtilization" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTransactionPriceCashConsiderationReceived" name="CollaborativeArrangementTransactionPriceCashConsiderationReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementMaterialPromisesManufacturingActivitiesTerm" name="CollaborativeArrangementMaterialPromisesManufacturingActivitiesTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTransactionPriceMilestonePaymentsReceivedAndReceivable" name="CollaborativeArrangementTransactionPriceMilestonePaymentsReceivedAndReceivable" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <xsd:element name="InventoryCurrentAndNoncurrentRawMaterialsNetOfReserves" id="bpmc_InventoryCurrentAndNoncurrentRawMaterialsNetOfReserves" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ScheduleOfCollaborationLossSharingTableTextBlock" id="bpmc_ScheduleOfCollaborationLossSharingTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="GavretoMember" id="bpmc_GavretoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AyvakitAndAyvakytMember" id="bpmc_AyvakitAndAyvakytMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementCommercializationReductionInSellingGeneralAndAdministrativeExpenses" id="bpmc_CollaborativeArrangementCommercializationReductionInSellingGeneralAndAdministrativeExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementGlobalDevelopmentActivitiesReductionInResearchAndDevelopmentExpenses" id="bpmc_CollaborativeArrangementGlobalDevelopmentActivitiesReductionInResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ScheduleOfAmountsRecognizedAsReductionsToExpensesCollaborativeArrangementTableTextBlock" id="bpmc_ScheduleOfAmountsRecognizedAsReductionsToExpensesCollaborativeArrangementTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LengoTherapeuticsIncMember" id="bpmc_LengoTherapeuticsIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AcquiredProductiveAssetsInProcessResearchAndDevelopmentExpensed" id="bpmc_AcquiredProductiveAssetsInProcessResearchAndDevelopmentExpensed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AssetAcquisitionConsiderationTransferredUpfrontPayment" id="bpmc_AssetAcquisitionConsiderationTransferredUpfrontPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssetAcquisitionConsiderationTransferredFutureContingentCashMilestonePayments" id="bpmc_AssetAcquisitionConsiderationTransferredFutureContingentCashMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssetAcquisitionConsiderationTransferredAdjustmentsNetIndebtednessTransactionExpensesAndOtherAdjustments" id="bpmc_AssetAcquisitionConsiderationTransferredAdjustmentsNetIndebtednessTransactionExpensesAndOtherAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesNet" id="bpmc_AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ZaiLabShanghaiCoLtdMember" id="bpmc_ZaiLabShanghaiCoLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementMaterialPromisesCombinedIntoDistinctPerformanceObligationNumber" id="bpmc_CollaborativeArrangementMaterialPromisesCombinedIntoDistinctPerformanceObligationNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDate" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDate" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenAfterFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenAfterFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenPriorToFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenPriorToFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="TerritorySpecificActivitiesManufacturingServicesAndRoyaltyMember" id="bpmc_TerritorySpecificActivitiesManufacturingServicesAndRoyaltyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ProteovantMember" id="bpmc_ProteovantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementClinicalTrialsSharedDevelopmentCost" id="bpmc_CollaborativeArrangementClinicalTrialsSharedDevelopmentCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ExternalResearchDevelopmentAndCommercialContractCostsNoncurrent" id="bpmc_ExternalResearchDevelopmentAndCommercialContractCostsNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ExternalResearchDevelopmentAndCommercialContractCosts" id="bpmc_ExternalResearchDevelopmentAndCommercialContractCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RocheCollaborationAndLicenseImmunotherapyAgreementPhaseIClinicalTrialsMember" id="bpmc_RocheCollaborationAndLicenseImmunotherapyAgreementPhaseIClinicalTrialsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtSecuritiesAvailableForSaleCreditRelatedImpairmentsCharges" id="bpmc_DebtSecuritiesAvailableForSaleCreditRelatedImpairmentsCharges" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CollaborativeArrangementTransactionPricePaymentCommitmentReduction" id="bpmc_CollaborativeArrangementTransactionPricePaymentCommitmentReduction" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RevenueFromContractWithCustomerIncludingAssessedTaxCumulativeRevenueCatchUp" id="bpmc_RevenueFromContractWithCustomerIncludingAssessedTaxCumulativeRevenueCatchUp" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementUpfrontPayment" id="bpmc_CollaborativeArrangementUpfrontPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementMilestonesPotentialContingentPayments" id="bpmc_CollaborativeArrangementMilestonesPotentialContingentPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TerritorySpecificActivitiesManufacturingAndResearchAndDevelopmentServicesMember" id="bpmc_TerritorySpecificActivitiesManufacturingAndResearchAndDevelopmentServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SixthStreetPartnersFinancingAgreementMember" id="bpmc_SixthStreetPartnersFinancingAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SixthStreetPartnersFinancingAgreementSeniorSecuredTermLoanFacilityMember" id="bpmc_SixthStreetPartnersFinancingAgreementSeniorSecuredTermLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SixthStreetPartnersFinancingAgreementSeniorSecuredDelayedDrawTermLoanFacilityMember" id="bpmc_SixthStreetPartnersFinancingAgreementSeniorSecuredDelayedDrawTermLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentVariableRateFloor" id="bpmc_DebtInstrumentVariableRateFloor" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SixthStreetPartnersFinancingAgreementSeniorSecuredTermLoanFacilitiesMember" id="bpmc_SixthStreetPartnersFinancingAgreementSeniorSecuredTermLoanFacilitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RoyaltyPharmaRoyaltyPurchaseAgreementMember" id="bpmc_RoyaltyPharmaRoyaltyPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RoyaltyPurchaseAgreementMilestonePaymentsAchievementOfSpecifiedNetSalesMilestonesMaximum" id="bpmc_RoyaltyPurchaseAgreementMilestonePaymentsAchievementOfSpecifiedNetSalesMilestonesMaximum" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesPercentageRate" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesPercentageRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedPercentageIncrease" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedPercentageIncrease" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesAmountMaximum" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesAmountMaximum" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalAmount" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedAmount" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRatio" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedRatio" id="bpmc_PurchaseAndSaleAgreementRoyaltiesFutureRoyaltyPaymentsAnnualWorldwideNetProductSalesCumulativeCapOfUpfrontInvestedCapitalRevenueTargetsNotAchievedRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="SixthStreetPartnersMember" id="bpmc_SixthStreetPartnersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TerritorySpecificActivitiesMember" id="bpmc_TerritorySpecificActivitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentFaceAmountPotentialAmount" id="bpmc_DebtInstrumentFaceAmountPotentialAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentCovenantsConsolidatedLiquidityPeriodCommencingFromDateTermLoanFundedToDateDayBeforeNextTermLoansFunded" id="bpmc_DebtInstrumentCovenantsConsolidatedLiquidityPeriodCommencingFromDateTermLoanFundedToDateDayBeforeNextTermLoansFunded" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtInstrumentCovenantsConsolidatedLiquidityPeriodCommencingFromDateTermLoanFundedToDateDayBeforeNextTermLoansFundedEachDayThereafter" id="bpmc_DebtInstrumentCovenantsConsolidatedLiquidityPeriodCommencingFromDateTermLoanFundedToDateDayBeforeNextTermLoansFundedEachDayThereafter" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NoncashInterestExpense" id="bpmc_NoncashInterestExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IdrxIncMember" id="bpmc_IdrxIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborationAndLicenseMember" id="bpmc_CollaborationAndLicenseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtDiscountsAndCapitalizedDebtClosingCosts" id="bpmc_DebtDiscountsAndCapitalizedDebtClosingCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SaleOfFutureRoyaltiesAndRevenuesMember" id="bpmc_SaleOfFutureRoyaltiesAndRevenuesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementTransactionPriceReduction" id="bpmc_CollaborativeArrangementTransactionPriceReduction" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementTransactionPriceResearchMilestoneAchievedCashConsideration" id="bpmc_CollaborativeArrangementTransactionPriceResearchMilestoneAchievedCashConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SixthStreetPartnersFutureRevenuePurchaseAgreementMember" id="bpmc_SixthStreetPartnersFutureRevenuePurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentTransactionsNumber" id="bpmc_DebtInstrumentTransactionsNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="SixthStreetPartnersFinancingArrangementsMember" id="bpmc_SixthStreetPartnersFinancingArrangementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NoncashCustomerConsideration" id="bpmc_NoncashCustomerConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="EquitySecuritiesWithoutReadilyDeterminableFairValueLicenseAgreementSharesReceived" id="bpmc_EquitySecuritiesWithoutReadilyDeterminableFairValueLicenseAgreementSharesReceived" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborationAndLicenseExcludingRelatedPartyMember" id="bpmc_CollaborationAndLicenseExcludingRelatedPartyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborationAndLicenseRelatedPartyMember" id="bpmc_CollaborationAndLicenseRelatedPartyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseRelatedPartyMember" id="bpmc_LicenseRelatedPartyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EquitySecuritiesWithoutReadilyDeterminableFairValueTransactionCosts" id="bpmc_EquitySecuritiesWithoutReadilyDeterminableFairValueTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateYearOnePositionsNumber" id="bpmc_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateYearOnePositionsNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughFiveNumber" id="bpmc_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughFiveNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtSecuritiesAvailableForSalePositionsNumber" id="bpmc_DebtSecuritiesAvailableForSalePositionsNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LesseeOperatingLeaseRenewalTermConsecutiveTermsNumber" id="bpmc_LesseeOperatingLeaseRenewalTermConsecutiveTermsNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationDomesticTaxOnForeignEarningsPercent" id="bpmc_EffectiveIncomeTaxRateReconciliationDomesticTaxOnForeignEarningsPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExcludingResearchAndDevelopmentPercent" id="bpmc_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExcludingResearchAndDevelopmentPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DeferredTaxAssetsResearchAndDevelopmentCapitalization" id="bpmc_DeferredTaxAssetsResearchAndDevelopmentCapitalization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredTaxAssetsRoyaltyPurchaseAgreementsMilestones" id="bpmc_DeferredTaxAssetsRoyaltyPurchaseAgreementsMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredTaxAssetsFinancingArrangementTransactions" id="bpmc_DeferredTaxAssetsFinancingArrangementTransactions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LargestCustomersLargestCustomerMember" id="bpmc_LargestCustomersLargestCustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LargestCustomersSecondLargestCustomerMember" id="bpmc_LargestCustomersSecondLargestCustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LargestCustomersThirdLargestCustomerMember" id="bpmc_LargestCustomersThirdLargestCustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LongTermDebtAndInterest" id="bpmc_LongTermDebtAndInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LongTermDebtAndInterestMaturityYearOne" id="bpmc_LongTermDebtAndInterestMaturityYearOne" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LongTermDebtAndInterestMaturityYearTwo" id="bpmc_LongTermDebtAndInterestMaturityYearTwo" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LongTermDebtAndInterestMaturityYearThree" id="bpmc_LongTermDebtAndInterestMaturityYearThree" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LongTermDebtAndInterestMaturityYearFour" id="bpmc_LongTermDebtAndInterestMaturityYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LongTermDebtAndInterestMaturityYearFive" id="bpmc_LongTermDebtAndInterestMaturityYearFive" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LongTermDebtAndInterestMaturityAfterYearFive" id="bpmc_LongTermDebtAndInterestMaturityAfterYearFive" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ScheduleOfMaturitiesOfLongTermDebtAndInterestTableTextBlock" id="bpmc_ScheduleOfMaturitiesOfLongTermDebtAndInterestTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementCollaborationProgramsNumberOptionPeriodEnded" id="bpmc_CollaborativeArrangementCollaborationProgramsNumberOptionPeriodEnded" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentTranchesPotentialNumber" id="bpmc_DebtInstrumentTranchesPotentialNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="CollaborativeArrangementTransactionPriceMilestonePaymentsReceived" id="bpmc_CollaborativeArrangementTransactionPriceMilestonePaymentsReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
</xsd:schema>
