99900 - Disclosure - Standard And Custom Axis Domain Defaults
link:presentationLink
link:calculationLink
link:definitionLink
00100 - Statement - Condensed Consolidated Balance Sheets
link:presentationLink
link:calculationLink
link:definitionLink
00200 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss
link:presentationLink
link:calculationLink
link:definitionLink
00400 - Statement - Condensed Consolidated Statements of Cash Flows
link:presentationLink
link:calculationLink
link:definitionLink
00405 - Statement - Condensed Consolidated Statements of Cash Flows (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
40401 - Disclosure - Fair Value of Financial Instruments (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40601 - Disclosure - Inventory - Capitalized (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40602 - Disclosure - Inventory - Balance Sheet Classification (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40802 - Disclosure - Property and Equipment, Net - Property and Equipment and Related Accumulated Depreciation (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40901 - Disclosure - Accrued Expenses (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41001 - Disclosure - Collaboration and License Agreements - General Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41002 - Disclosure - Collaboration and License Agreements - Transaction Price (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41003 - Disclosure - Collaboration and License Agreements - Sale of Stock (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41108 - Disclosure - Stock-based Compensation - Stock-based Compensation Expense - By Type (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41402 - Disclosure - Leases - Components of Lease Expense (Details)
link:presentationLink
link:calculationLink
link:definitionLink
00090 - Document - Document and Entity Information
link:presentationLink
link:calculationLink
link:definitionLink
00105 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
00300 - Statement - Condensed Consolidated Statements of Stockholders' Equity
link:presentationLink
link:calculationLink
link:definitionLink
10101 - Disclosure - Nature of Business
link:presentationLink
link:calculationLink
link:definitionLink
10201 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements
link:presentationLink
link:calculationLink
link:definitionLink
10401 - Disclosure - Fair Value of Financial Instruments
link:presentationLink
link:calculationLink
link:definitionLink
10501 - Disclosure - Product Revenue Reserves and Allowances
link:presentationLink
link:calculationLink
link:definitionLink
10601 - Disclosure - Inventory
link:presentationLink
link:calculationLink
link:definitionLink
10701 - Disclosure - Restricted Cash
link:presentationLink
link:calculationLink
link:definitionLink
10801 - Disclosure - Property and Equipment, Net
link:presentationLink
link:calculationLink
link:definitionLink
10901 - Disclosure - Accrued Expenses
link:presentationLink
link:calculationLink
link:definitionLink
11001 - Disclosure - Collaboration and License Agreements
link:presentationLink
link:calculationLink
link:definitionLink
11101 - Disclosure - Stock-based Compensation
link:presentationLink
link:calculationLink
link:definitionLink
11201 - Disclosure - Net Loss Per Share
link:presentationLink
link:calculationLink
link:definitionLink
11301 - Disclosure - Income Taxes
link:presentationLink
link:calculationLink
link:definitionLink
11501 - Disclosure - Commitments
link:presentationLink
link:calculationLink
link:definitionLink
11801 - Disclosure - Subsequent Events
link:presentationLink
link:calculationLink
link:definitionLink
20202 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Policies)
link:presentationLink
link:calculationLink
link:definitionLink
30403 - Disclosure - Fair Value of Financial Instruments (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
30503 - Disclosure - Product Revenue Reserves and Allowances (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
30603 - Disclosure - Inventory (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
30803 - Disclosure - Property and Equipment, Net (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
30903 - Disclosure - Accrued Expenses (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
31003 - Disclosure - Collaboration and License Agreements (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
31103 - Disclosure - Stock-based Compensation (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
31203 - Disclosure - Net Loss Per Share (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
40501 - Disclosure - Product Revenue Reserves and Allowances - Product Revenue (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40503 - Disclosure - Product Revenue Reserves and Allowances - Revenue-related Reserves (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40603 - Disclosure - Inventory - Write-down (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40801 - Disclosure - Property and Equipment, Net - Estimated Useful Lives (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40803 - Disclosure - Property and Equipment, Net - Depreciation Expense (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41004 - Disclosure - Collaboration and License Agreements - Manufacturing and Research and Development Services (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41005 - Disclosure - Collaboration and License Agreements - Revenue Recognized (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41006 - Disclosure - Collaboration and License Agreements - Reduction in Expenses (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41007 - Disclosure - Collaboration and License Agreements - Change in Contract with Customer, Liability (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41008 - Disclosure - Collaboration and License Agreements - Contract Assets (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41009 - Disclosure - Collaboration and License Agreements - Contract Liabilities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41010 - Disclosure - Collaboration and License Agreements - Performance Obligations (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41010 - Disclosure - Collaboration and License Agreements - Performance Obligations Default (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41101 - Disclosure - Stock-based Compensation - 2015 Stock Option and Incentive Plan (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41102 - Disclosure - Stock-based Compensation - 2020 Inducement Plan (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41104 - Disclosure - Stock-based Compensation - Unrecognized Compensation Costs (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41105 - Disclosure - Stock-based Compensation - Restricted Stock Units (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41106 - Disclosure - Stock-based Compensation - Employee Stock Purchase Plan (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41109 - Disclosure - Stock-based Compensation - Stock-based Compensation Expense - By Classification (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41201 - Disclosure - Net Income Per Share (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41401 - Disclosure - Leases - Remaining Lease Terms (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41601 - Disclosure - Subsequent Events (Details)
link:presentationLink
link:calculationLink
link:definitionLink
11401 - Disclosure - Leases
link:presentationLink
link:calculationLink
link:definitionLink
31403 - Disclosure - Leases (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
40101 - Disclosure - Nature of Business (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40304 - Disclosure - Marketable Securities - Remaining Maturities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40502 - Disclosure - Product Revenue Reserves and Allowances - Product Revenue Allowance and Reserve (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40701 - Disclosure - Restricted Cash (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41103 - Disclosure - Stock-based Compensation - Stock Options (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41107 - Disclosure - Stock-based Compensation - Stock-based Compensation Expense - General Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41403 - Disclosure - Leases - Cash Flow Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41404 - Disclosure - Leases - Weighted Average Remaining Lease-term and Weighted Average Discount Rate (Details)
link:presentationLink
link:calculationLink
link:definitionLink