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  <element id="bpmc_CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedEntity" name="CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedEntity" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedCounterparty" name="CollaborativeArrangementPercentageOfGlobalDevelopmentCostsSharedCounterparty" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementUpfrontPaymentCashPaymentReceived" name="CollaborativeArrangementUpfrontPaymentCashPaymentReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMilestonesCashPaymentsReceived" name="CollaborativeArrangementMilestonesCashPaymentsReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementInventoryPurchasedByCounterparty" name="CollaborativeArrangementInventoryPurchasedByCounterparty" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMaterialPromisesNumber" name="CollaborativeArrangementMaterialPromisesNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_RevenuePerformanceObligationPerformanceObligationsNumber" name="RevenuePerformanceObligationPerformanceObligationsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMaterialComponentsNumber" name="CollaborativeArrangementMaterialComponentsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_CollaborativeArrangementLicensedProductTermFromFirstCommercialSale" name="CollaborativeArrangementLicensedProductTermFromFirstCommercialSale" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementLicenseOptionRightsNumber" name="CollaborativeArrangementLicenseOptionRightsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsWithExclusiveCommercializationRightsNumber" name="CollaborativeArrangementCollaborationProgramsWithExclusiveCommercializationRightsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsNumber" name="CollaborativeArrangementCollaborationProgramsNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsLicensedProductsCommercializationRightsCounterpartyExercisesOptionCounterpartyReceivesWorldwideExclusivityNumber" name="CollaborativeArrangementCollaborationProgramsLicensedProductsCommercializationRightsCounterpartyExercisesOptionCounterpartyReceivesWorldwideExclusivityNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementCollaborationProgramsLicensedProductsCommercializationRightsCounterpartyExercisesOptionEntityRetainsDomesticAndCounterpartyReceivesInternationalNumber" name="CollaborativeArrangementCollaborationProgramsLicensedProductsCommercializationRightsCounterpartyExercisesOptionEntityRetainsDomesticAndCounterpartyReceivesInternationalNumber" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementOptionFeesAndMilestonesContingentPaymentsEligibleToReceive" name="CollaborativeArrangementOptionFeesAndMilestonesContingentPaymentsEligibleToReceive" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriod" name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveNotBeenCommerciallySold" name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveNotBeenCommerciallySold" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveBeenCommerciallySold" name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodAfterOptionExerciseIfLicensedProductsHaveBeenCommerciallySold" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMilestonesResearchMilestonesAchieved" name="CollaborativeArrangementMilestonesResearchMilestonesAchieved" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementManufacturingAndResearchAndDevelopmentServicesRelatedToGlobalDevelopmentActivitiesNetOfCostSharingPayments" name="CollaborativeArrangementManufacturingAndResearchAndDevelopmentServicesRelatedToGlobalDevelopmentActivitiesNetOfCostSharingPayments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <element id="bpmc_InventoryCurrentAndNoncurrentNet" name="InventoryCurrentAndNoncurrentNet" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InventoryCurrentAndNoncurrentWorkInProcessNetOfReserves" name="InventoryCurrentAndNoncurrentWorkInProcessNetOfReserves" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_InventoryCurrentAndNoncurrentFinishedGoodsNetOfReserves" name="InventoryCurrentAndNoncurrentFinishedGoodsNetOfReserves" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_ScheduleOfInventoryCurrentAndNoncurrentTableTextBlock" name="ScheduleOfInventoryCurrentAndNoncurrentTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMaterialPromisesManufacturingActivitiesTerm" name="CollaborativeArrangementMaterialPromisesManufacturingActivitiesTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="bpmc_CollaborativeArrangementMilestonesAchieved" name="CollaborativeArrangementMilestonesAchieved" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" abstract="false" />
  <xsd:element name="InventoryCurrentAndNoncurrentRawMaterialsNetOfReserves" id="bpmc_InventoryCurrentAndNoncurrentRawMaterialsNetOfReserves" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ScheduleOfCollaborationLossSharingTableTextBlock" id="bpmc_ScheduleOfCollaborationLossSharingTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="GavretoMember" id="bpmc_GavretoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AyvakitAndAyvakytMember" id="bpmc_AyvakitAndAyvakytMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementCommercializationReductionInSellingGeneralAndAdministrativeExpenses" id="bpmc_CollaborativeArrangementCommercializationReductionInSellingGeneralAndAdministrativeExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementGlobalDevelopmentActivitiesReductionInResearchAndDevelopmentExpenses" id="bpmc_CollaborativeArrangementGlobalDevelopmentActivitiesReductionInResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ScheduleOfAmountsRecognizedAsReductionsToExpensesCollaborativeArrangementTableTextBlock" id="bpmc_ScheduleOfAmountsRecognizedAsReductionsToExpensesCollaborativeArrangementTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ZaiLabShanghaiCoLtdMember" id="bpmc_ZaiLabShanghaiCoLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementMaterialPromisesCombinedIntoDistinctPerformanceObligationNumber" id="bpmc_CollaborativeArrangementMaterialPromisesCombinedIntoDistinctPerformanceObligationNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDate" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDate" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenAfterFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenAfterFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenPriorToFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" id="bpmc_CollaborativeArrangementTerminationCounterpartyWrittenNoticePeriodPeriodFromEffectiveDateGivenPriorToFirstCommercialSaleOfLicensedProductInCounterpartyTerritory" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="TerritorySpecificActivitiesManufacturingServicesAndRoyaltyMember" id="bpmc_TerritorySpecificActivitiesManufacturingServicesAndRoyaltyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ProteovantMember" id="bpmc_ProteovantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementClinicalTrialsSharedDevelopmentCost" id="bpmc_CollaborativeArrangementClinicalTrialsSharedDevelopmentCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ExternalResearchDevelopmentAndCommercialContractCostsNoncurrent" id="bpmc_ExternalResearchDevelopmentAndCommercialContractCostsNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ExternalResearchDevelopmentAndCommercialContractCosts" id="bpmc_ExternalResearchDevelopmentAndCommercialContractCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RocheCollaborationAndLicenseImmunotherapyAgreementPhaseIClinicalTrialsMember" id="bpmc_RocheCollaborationAndLicenseImmunotherapyAgreementPhaseIClinicalTrialsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtSecuritiesAvailableForSaleCreditRelatedImpairmentsCharges" id="bpmc_DebtSecuritiesAvailableForSaleCreditRelatedImpairmentsCharges" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CollaborativeArrangementMilestonesCashPaymentsReceivedAggregate" id="bpmc_CollaborativeArrangementMilestonesCashPaymentsReceivedAggregate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CollaborativeArrangementTransactionPricePaymentCommitmentReduction" id="bpmc_CollaborativeArrangementTransactionPricePaymentCommitmentReduction" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RevenueFromContractWithCustomerIncludingAssessedTaxNet" id="bpmc_RevenueFromContractWithCustomerIncludingAssessedTaxNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RevenueFromContractWithCustomerIncludingAssessedTaxCumulativeRevenueCatchUp" id="bpmc_RevenueFromContractWithCustomerIncludingAssessedTaxCumulativeRevenueCatchUp" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementUpfrontPayment" id="bpmc_CollaborativeArrangementUpfrontPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementMilestonesPotentialContingentPayments" id="bpmc_CollaborativeArrangementMilestonesPotentialContingentPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TerritorySpecificActivitiesManufacturingAndResearchAndDevelopmentServicesMember" id="bpmc_TerritorySpecificActivitiesManufacturingAndResearchAndDevelopmentServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
</xsd:schema>
