SEC Filing | Blueprint Medicines Corp.

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SEC FORM 4 SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

FMR LLC

(Last)

(First)

(Middle)

245 SUMMER STREET

(Street)

BOSTON

02210

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
Blueprint Medicines Corp [ BPMC ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)	X	Other (specify below)
See Remark 1

3. Date of Earliest Transaction (Month/Day/Year)
11/24/2015

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	11/24/2015		S		161,271	D	$20.14⁽¹⁾	552,313	I	Shares held by persons and entities whose shares are subject to reporting by the undersigned.

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)

Explanation of Responses:

1. The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $19.63 to $20.56. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

Remarks:

Remark 1: Edward C. Johnson 3d is a Director and the Chairman of FMR LLC and Abigail P. Johnson is a Director, the Vice Chairman, the Chief Executive Officer and the President of FMR LLC. Members of the family of Edward C. Johnson 3d, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR LLC, representing 49% of the voting power of FMR LLC. The Johnson family group and all other Series B shareholders have entered into a shareholders' voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders' voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR LLC. The address of Edward C. Johnson 3d and Abigail P. Johnson is c/o FMR LLC, 245 Summer Street, Boston, MA 02110. Remark 2: The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, the undersigned are the beneficial owners of any securities reported herein.

	Marc R. Bryant, Duly authorized under Powers of Attorney, by and on behalf of FMR LLC and its direct and indirect subsidiaries, Edward C. Johnson 3d and Abigail P. Johnson	11/25/2015
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

POWER OF ATTORNEY

		Effective September 23, 2015, the undersigned does hereby appoint
Marc R. Bryant, with full power of substitution, as the true and lawful
attorney of the undersigned, with full power and authority to execute such
documents and to make such regulatory or other filings and amendments thereto
as shall from time to time be required pursuant to the Securities Exchange Act
of 1934, as amended, any rules or regulations adopted thereunder, and such
other U.S. and non-U.S. laws, rules or regulations as shall from time to time be
applicable in respect of the beneficial ownership of securities directly or
indirectly attributable to the undersigned and its direct and indirect
subsidiaries, and generally to do all such things in the name and on behalf
of the indersigned in connection therewith as said attorney-in-fact deems
necessary or appropriate to cause such filings to be completed and filed.


		This Power of Attorney shall remain in full force and effect only
for such time as Marc R. Bryant shall continue to be an officer of Fidelity
Management & Research Company, provided that, notwithstanding the foregoing,
this Power of Attorney may be revoked at any time by the undersigned in writing.


		This Power of Attorney has been executed as of the 23rd day of
September, 2015.


	FMR LLC

  	By /s/ Abigail P. Johnson
  	Abigail P. Johnson
  	President




POWER OF ATTORNEY

      WHEREAS, Edward C. Johnson 3d has appointed Scott C. Goebel, with full
power of substitution, as his true and lawful attorney, with full power and
authority to execute such documents and to make such regulatory or other
filings and amendments thereto (the "Filings") as shall from time to time be
required pursuant to the Securities Exchange Act of 1934, as amended, any rules
or regulations adopted thereunder, and such other U.S. and non-U.S. laws, rules
or regulations as shall from time to time be applicable in respect of the
beneficial ownership of securities directly or indirectly attributable to him.

      NOW, THEREFORE, the undersigned hereby constitutes and appoints Marc
R. Bryant as his substitute, to have all the powers of the undersigned with
respect to the Filings, when the undersigned is unavailable.

      The Power of Attorney shall remain in full force and effect only for
such time as the undersigned shall continue to be an officer of Fidelity
Management & Research Company, provided that, notwithstanding the foregoing,
this Power of Attorney may be revoked at any time by the undersigned in writing.


						  /s/ Scott C. Goebel
						Scott C. Goebel

Dated: October 12, 2015



POWER OF ATTORNEY

      WHEREAS, Abigail P. Johnson has appointed Scott C. Goebel, with full
power of substitution, as her true and lawful attorney, with full power and
authority to execute such documents and to make such regulatory or other
filings and amendments thereto (the "Filings") as shall from time to time be
required pursuant to the Securities Exchange Act of 1934, as amended, any rules
or regulations adopted thereunder, and such other U.S. and non-U.S. laws, rules
or regulations as shall from time to time be applicable in respect of the
beneficial ownership of securities directly or indirectly attributable to her.

      NOW, THEREFORE, the undersigned hereby constitutes and appoints Marc
R. Bryant as his substitute, to have all the powers of the undersigned with
respect to the Filings, when the undersigned is unavailable.

      The Power of Attorney shall remain in full force and effect only for
such time as the undersigned shall continue to be an officer of Fidelity
Management & Research Company, provided that, notwithstanding the foregoing,
this Power of Attorney may be revoked at any time by the undersigned in writing.


						  /s/ Scott C. Goebel
						Scott C. Goebel

Dated: October 12, 2015